Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals
Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals
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DOI：
10.1371/journal.pone.0202683
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发表时间：
2018-08-28
期刊：
影响因子：
3.7
通讯作者：
Lubrano, Carla
中科院分区：
文献类型：
--
作者：
Watanabe, Mikiko;Masieri, Simonetta;Lubrano, Carla
背景由于暴饮暴食或减少体力活动导致的能量摄入和消耗之间缺乏平衡似乎并不能完全解释我们所面临的肥胖流行病，因此正在评估其他因素。镍（Ni）是一种普遍存在的重金属，存在于多种健康状况中。关于这一点，欧洲食品安全局最近发布了关于膳食镍对人体健康可能有害影响的警报，因为目前一些国家的镍膳食摄入量水平。临床前研究也表明其作为内分泌干扰物的作用，并将其暴露与能量代谢和葡萄糖稳态失调联系起来。镍过敏是常见的在一般人群中，但初步的数据表明，它是更普遍的超重patients.ObjectivesThe本研究的目的是评估存在镍过敏及其与代谢和内分泌配置文件在超重和肥胖individual.MethodsWe评估了1128连续超重和肥胖门诊患者。784人怀疑对镍过敏，666人进行了评估。镍过敏的存在及其与体重指数（BMI）、身体成分、代谢参数和激素水平进行了评估。结果我们报告说，镍过敏是更常见的存在体重过剩，并与更差的代谢参数和受损的生长激素分泌。结论我们证实，镍过敏是更常见的，肥胖患者，我们首次报告了其与人类受试者的代谢参数和GH-IGF 1轴功能受损的关系。
BackgroundA lack of balance between energy intake and expenditure due to overeating or reduced physical activity does not seem to explain entirely the obesity epidemic we are facing, and further factors are therefore being evaluated. Nickel (Ni) is a ubiquitous heavy metal implied in several health conditions. Regarding this, the European Food Safety Authority has recently released an alert on the possible deleterious effects of dietary Ni on human health given the current levels of Ni dietary intake in some countries. Pre-clinical studies have also suggested its role as an endocrine disruptor and have linked its exposure to energy metabolism and glucose homeostasis dysregulation. Ni allergy is common in the general population, but preliminary data suggest it being even more widespread among overweight patients.ObjectivesThe aim of this study has been to evaluate the presence of Ni allergy and its association with the metabolic and endocrine profile in overweight and obese individuals.MethodsWe have evaluated 1128 consecutive overweight and obese outpatients. 784 were suspected of being allergic to Ni and 666 were assessed for it. Presence of Ni allergy and correlation with body mass index (BMI), body composition, metabolic parameters and hormonal levels were evaluated.ResultsWe report that Ni allergy is more frequent in presence of weight excess and is associated with worse metabolic parameters and impaired Growth Hormone secretion.ConclusionsWe confirm that Ni allergy is more common in obese patients, and we report for the first time its association with worse metabolic parameters and impaired function of the GH-IGF1 axis in human subjects.