Tea consumption and basal cell and squamous cell skin cancer: Results of a case-control study
Tea consumption and basal cell and squamous cell skin cancer: Results of a case-control study
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DOI：
10.1016/j.jaad.2006.11.038
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发表时间：
2007-05-01
影响因子：
13.8
通讯作者：
Karagas, Margaret R.
中科院分区：
文献类型：
--
作者：
Rees, Judy R.;Stukel, Therese A.;Karagas, Margaret R.
背景资料：茶成分，包括多酚，被假设有化学预防特性，并抑制诱发皮肤癌的动物模型。目的：探讨经常饮茶与皮肤癌的关系（>= 1杯/天，>= 1个月）和鳞状细胞癌（SCC）和基底细胞癌（BCC）的发病率。一项以人群为基础的病例对照研究，包括770名基底细胞癌患者、696名鳞状细胞癌患者和715名年龄和性别匹配的对照组。在调整了年龄、性别和痛苦的晒伤史后，经常喝茶与SCC的风险显著降低有关（比值比[OR] = 0.70; 95%置信区间[CI] 0.53-0.92），尤其是在长期饮酒者中（>= 47年的消费：SCC，OR = 0.49; 95% CI 0.29-0.83;趋势P = .008）
Background: Tea constituents, including polyphenols, are hypothesized to have chemopreventive properties, and inhibit the induction of skin cancers in animal models.Objective: To explore the association between regular tea consumption (>= 1 cup/d for >= 1 month) and the incidence of squamous cell (SCC) and basal cell (BCC) carcinomas.Methods: A population-based case-control study of 770 individuals with BCC, 696 with SCC, and 715 age- and sex-matched control subjects.Results: After adjustment for age, sex, and lifetime history of painful sunburns, ever having consumed tea regularly was associated with a significantly lower risk of SCC (odds ratio [OR] = 0.70; 95% confidence interval [CI] 0.53-0.92), especially among long-term drinkers (>= 47 years consumption: SCC, OR = 0.49; 95% CI 0.29-0.83; P for trend = .008) and among those consuming