Can cinnamon spice down autoimmune diseases?
Can cinnamon spice down autoimmune diseases?
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DOI：
10.33140/jcei.05.06.01
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Pahan K
中科院分区：
文献类型：
--
作者：
Pahan S;Pahan K
自身免疫性疾病是一组可怕的人类疾病，一直是研究人员的浓厚兴趣。由于其复杂性和广谱性，科学家们还不能确定这组疾病的发病机制和描绘有效的治疗方法。然而，越来越清楚的是，调节性T细胞（Treg）的数量和功能的减少，自身反应性Th 1/Th 17细胞的增加以及相关的免疫调节和炎症参与许多自身免疫性疾病的发病机制。肉桂（Cinnamonum verum或Cinnamonum pyramidum）是一种广泛使用的天然香料和调味成分，其代谢产物苯甲酸钠（NaB）是一种食品添加剂，也是FDA批准的治疗非酮症高甘氨酸血症（NKH）和尿素循环障碍（UCD）的药物。最近的研究表明，粉末或提取物形式的肉桂和NaB能够调节不同的自身免疫途径，以及保护动物免受不同的自身免疫性疾病。在这里，我们做了一个诚实的尝试，用现有的抗自身免疫机制来描述这些证据，并分析肉桂补充剂是否可以用来控制自身免疫性疾病的愤怒。
Autoimmune diseases are one of the dreadful group of human diseases that have always been of keen interest to researchers. Due to complex and broad-spectrum nature, scientists are not yet able to pinpoint the pathogenesis of and delineate effective therapy against this group of diseases. However, it is becoming clear that a decrease in number and function of T regulatory cells (Treg), an increase in autoreactive Th1/Th17 cells and associated immunomodulation and inflammation participate in the pathogenesis of many autoimmune diseases. Cinnamon (Cinnamonum verum or Cinnamonum cassia) is a widely used natural spice and flavoring ingredient and its metabolite sodium benzoate (NaB) is a food-additive and FDA-approved drug against nonketotic hyperglycinemia (NKH) and urea cycle disorders (UCD). Recent studies indicate that cinnamon either in powder or extract form and NaB are capable of modulating different autoimmune pathways as well as protecting animals from different autoimmune disorders. Here, we have made an honest attempt to delineate such pieces of evidence with available anti-autoimmune mechanisms and analyze whether cinnamon supplements could be used to control the fury of autoimmune disorders.