An evaluation of iron-dextran supplementation in piglets administered by injection on the first, third or fourth day after birth
An evaluation of iron-dextran supplementation in piglets administered by injection on the first, third or fourth day after birth
复制标题
DOI：
10.1053/rvsc.1998.0223
复制
发表时间：
1999-06-01
影响因子：
2.4
通讯作者：
Framstad, T
中科院分区：
文献类型：
--
作者：
Egeli, AK;Framstad, T
本研究的目的是评价在仔猪出生后第一天、第三天或第四天给予右旋糖酐铁注射液对血液学的影响。使用先进的自动血液分析仪Technicon H*1（R）进行全血细胞计数和白细胞分类计数，用于分析血液。本研究包括6窝挪威长白猪×约克郡仔猪。在出生后的第一天（第1天），每窝（分窝）中的一半仔猪皮下注射180 mg铁作为铁-葡聚糖（1.5 ml Idofer（R））。其中两窝未处理的小猪在第3天注射相同量的右旋糖酐铁，其余四窝的小猪在第4天注射相同量的右旋糖酐铁。在第1、3或4、7、14和21天对仔猪称重并采集血样。与第三天或第四天注射相比，第1天注射对红细胞生成有反应，但对白细胞计数无反应。组间血液学参数的差异在第7天最大。第1天处理的两组仔猪的血红蛋白浓度（Hb）+/-SD分别为92 g/L（-1）（+/-9）和94 g/L（-1）（+/-9），第3天处理的仔猪的Hb为81 g/L（-1）（+/-7），第4天处理的仔猪在第7天的Hb为78 g/L（-1）（+/-7）。在第14天和第21天，组间无差异。本研究表明，一些仔猪贫血，并在第1天皮下注射铁。
The aims of the study were to evaluate the effect of iron-dextran injection given on the first, third or fourth day after birth on haematology in piglets. An advanced automated blood analyser; Technicon H*1(R), which performs a complete blood cell count and leukocyte differential counts was used to analyse the blood. Six litters of Norwegian Landrace x Yorkshire piglets were included in the study. The day after birth (day 1), half of the piglets in each litter (split litters) were injected subcutaneously with 180 mg iron as iron-dextran (1.5 ml Idofer(R)). The untreated piglets from two of the litters were injected with the same amount of iron-dextran on day 3, and those from the remaining four litters on day 4. The piglets were weighed and blood samples collected on days 1, 3 or 4, 7, 14 and 21. Erythropoiesis, but not leukocyte count, responded to injection on day 1 compared with injection on the third or fourth day. The difference between groups in haematological parameters was greatest on day 7. The two groups of piglets treated on day 1 had a haemoglobin concentration (Hb) +/-SD of 92 g litre(-1) (+/-9) and 94 g litre(-1) (+/-9), and the piglets treated on day 3 had a Hb of 81 g litre(-1) (+/-7) and the one treated on day 4 had a Hb of 78 g litre(-1) (+/-7) on day 7. On days 14 and 21 there were no differences between groups. This study indicates that some piglets were anaemic and responded to subcutanous iron injection on day 1.