Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis
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DOI：
10.1097/00004872-199816121-00033
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发表时间：
1998-12-01
影响因子：
4.9
通讯作者：
Webb, DJ
中科院分区：
文献类型：
--
作者：
Wilkinson, IB;Fuchs, SA;Webb, DJ
目的本研究的目的是确定重复性的脉搏波速度（PWV）和增强指数（Alx）测量使用脉搏波分析（PWA），在其使用之前，在大规模的临床试验。对有和没有一系列公认的心血管危险因素的受试者进行了研究，以提供广泛的值。在临床环境中简要介绍该技术后进行测量。两名观察员记录了24名受试者的主动脉和肱动脉PWV，各两次，随机顺序。在一项单独的研究中，两名不同的观察员使用PWA确定33名受试者的空气，每个人在两个场合，以随机顺序。结果：肱动脉PWV为8.65 ± 1.58 m/s（范围6.16-10.95 m/s），主动脉PWV为8.15 ± 3.01 m/s（5.01-17.97 m/s）。肱动脉PWV的观察者内变异性为0.14 +/- 0.82 m/s，主动脉PWV为0.07 +/- 1.17 m/s。相应的观察者间值为-0.44 +/- 1.09 m/s和-0.30 +/- 1.25 m/s。空气的范围为-15.0至+45.0%，组平均值为+19.6 +/-12.0%。观察者内差异为0.49 ± 5.37%，观察者间差异为0.23 ± 3.80%。结论PWA是一种简单、重复性好的PWV和Air测量方法。与其他工人使用不同方法报告的结果一致。因此，PWA可能适用于调查血管僵硬度临床相关性的大规模人群和干预研究。J Hypertens 1998，16：2079-2084（C）1998 Lippincott威廉姆斯& Wilkins.
Objective The aim of this study was to determine the reproducibility of pulse wave velocity (PWV) and augmentation index (Alx) measured using pulse wave analysis (PWA), prior to its use in large-scale clinical trials.Methods Arterial pressure waveforms were recorded and analysed using an established technique (Sphygmocor). Subjects with and without a range of recognized cardiovascular risk factors were studied to provide a wide range of values. Measurements were made after a brief introduction to the technique in a clinical setting. Two observers recorded aortic and brachial PWV in 24 subjects, each on two occasions, in a random order. In a separate study, two different observers used PWA to determine Air in 33 subjects, each on two occasions, in a random order. Data were analysed using Bland-Altman plots and presented as mean +/- SD.Results Brachial PWV was 8.65 +/- 1.58 m/s (range 6.16-10.95 m/s) and aortic PWV was 8.15 +/- 3.01 m/s (5.01-17.97 m/s). Within-observer variability was 0.14 +/- 0.82 m/s for brachial PWV and 0.07 +/- 1.17 m/s for aortic PWV. Corresponding between-observer values were -0.44 +/- 1.09 m/s and -0.30 +/- 1.25 m/s. Air ranged from -15.0 to +45.0%, with a group mean of +19.6 +/- 12.0%. The within-observer difference was 0.49 +/- 5.37% and between-observer difference 0.23 +/- 3.80%.Conclusion PWA is a simple and reproducible technique with which to measure PWV and Air. Reproducibility accords with that reported by other workers using different methodologies. PWA may, therefore, be suitable for large-scale population and intervention studies investigating the clinical relevance of vascular stiffness. J Hypertens 1998, 16:2079-2084 (C) 1998 Lippincott Williams & Wilkins.