Postsynaptic assembly: a role for Wnt signaling.

Postsynaptic assembly: a role for Wnt signaling.
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DOI:
10.1002/dneu.22138
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发表时间:
2014-08
影响因子:
3
通讯作者:
Salinas, Patricia C.
Salinas, Patricia C.
中科院分区:
医学3区
文献类型:
--
作者:
Stamatakou, Eleanna;Salinas, Patricia C.

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突触的形成需要突触前末梢和突触后侧的协调形成,突触前末梢包含神经递质释放的机制,突触后侧具有神经递质接收的机制。为了协调突触前和突触后的组装,需要跨越突触的信号。Wnt分泌的蛋白质是众所周知的突触发生因子,其在多种生物体中促进突触前组分的募集。然而,最近的研究表明,Wnt直接作用于中枢和外周突触的突触后侧,以促进突触后发育和突触强度。本文综述了Wnts在中枢突触和神经肌肉接头突触后发育中的作用。© 2013作者。出版社:Wiley Periodicals,Inc.开发神经生物学74:818-827,2014年
Synapse formation requires the coordinated formation of the presynaptic terminal, containing the machinery for neurotransmitter release, and the postsynaptic side that possesses the machinery for neurotransmitter reception. For coordinated pre- and postsynaptic assembly signals across the synapse are required. Wnt secreted proteins are well-known synaptogenic factors that promote the recruitment of presynaptic components in diverse organisms. However, recent studies demonstrate that Wnts act directly onto the postsynaptic side at both central and peripheral synapses to promote postsynaptic development and synaptic strength. This review focuses on the role of Wnts in postsynaptic development at central synapses and the neuromuscular junction. © 2013 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 74: 818–827, 2014
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