HYPERSPLENISM IN HOMOZYGOUS SICKLE-CELL DISEASE IN SAUDI-ARABIA
HYPERSPLENISM IN HOMOZYGOUS SICKLE-CELL DISEASE IN SAUDI-ARABIA
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DOI：
10.1080/02724936.1985.11748380
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发表时间：
1985-01-01
影响因子：
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通讯作者：
SALAMAH, MM
中科院分区：
文献类型：
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作者：
MALLOUH, AA;SALAMAH, MM
Black children with homozygous sickle-cell disease usually have anatomic asplenia by 6-8 years of age. In the Eastern Province of Saudi Arabia, sickle-cell disease runs a benign course. Here we report six sicklers with hypersplenism as manifested by 1: splenomegaly (6/6); 2: persistent thrombocytopenia (6/6); 3: increasing severity of anaemia with the need for repeated blood transfusion (5/6); 4: leukopenia (1/6); 5: high reticulocyte count (6/6); 6: circulating nucleated red blood cells (5/6). All improved after splenectomy, with resolution of the thrombocytopenia and leukopenia, improvement in the degree of anaemia, decrease in the reticulocytes and disappearance of circulating nucleated red blood cells.
