Multiple myeloma: patient outcomes in real-world practice.
Multiple myeloma: patient outcomes in real-world practice.
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DOI：
10.1111/bjh.14213
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发表时间：
2016-10
影响因子：
6.5
通讯作者：
Cavo M
中科院分区：
文献类型：
--
作者：
Yong K;Delforge M;Driessen C;Fink L;Flinois A;Gonzalez-McQuire S;Safaei R;Karlin L;Mateos MV;Raab MS;Schoen P;Cavo M
随着越来越多的治疗多发性骨髓瘤的方法，它是及时检查的过程患者的旅程。我们调查了比利时、法国、德国、意大利、西班牙、瑞士和英国的患者特征、治疗持续时间和结果以及整个治疗途径的症状负担。共有435名医生回顾了4997份患者病历。在过去12个月内，各国诊断为多发性骨髓瘤的患者概况相似；骨痛是最常见的表现。一线治疗的中位持续时间为6个月，随后的中位无治疗间隔为10个月；随着治疗线的增加，这两种情况都减少了，进展时间也减少了。治疗医师评估的反应深度也随着每增加一条治疗线而下降：74%的患者在一线至少达到了非常好的部分反应，而在第五线只有11%。更深的反应与更长的进展时间相关，尽管这些是由医生判断的。毒性和合并症随着治疗线的延长而增加，并且更有可能导致停止治疗。这些真实世界的数据提供了对临床实践中患者结果和治疗决策的深入了解。
With increasing number of therapies available for the treatment of multiple myeloma, it is timely to examine the course of patients' journeys. We investigated patient characteristics, treatment durations and outcomes, and symptom burden across the treatment pathway in Belgium, France, Germany, Italy, Spain, Switzerland and the UK. In total, 435 physicians retrospectively reviewed 4997 patient charts. Profiles of patients diagnosed with multiple myeloma during the last 12 months were similar across countries; bone pain was the most common presentation. Median duration of first‐line therapy was 6 months, followed by a median treatment‐free interval of 10 months; both these decreased with increasing lines of therapy, as did time to progression. Depth of response, as assessed by the treating physician, also decreased with each additional line of therapy: 74% of patients achieved at least a very good partial response at first line, compared with only 11% at fifth line. Deeper responses were associated with longer time to progression, although these were physician‐judged. Toxicities and co‐morbidities increased with later treatment lines, and were more likely to have led to discontinuation of treatment. These real‐world data provide an insight into patient outcomes and treatment decisions being made in clinical practice.
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影响因子：
2.7
作者：
Rifkin, Robert M.;Abonour, Rafat;Durie, Brian G. M.
通讯作者：
Durie, Brian G. M.
影响因子：
3.1
作者：
Birgegard, Gunnar;Gascon, Pere;Ludwig, Heinz
通讯作者：
Ludwig, Heinz
影响因子：
3.1
作者：
Acaster, S.;Gaugris, S.;Lloyd, A. J.
通讯作者：
Lloyd, A. J.
影响因子：
11.4
作者：
通讯作者：
--
影响因子：
12.8
作者：
Offidani, M.;Corvatta, L.;Maracci, L.;Liberati, A. M.;Ballanti, S.;Attolico, I.;Caraffa, P.;Alesiani, F.;di Toritto, T. Caravita;Gentili, S.;Tosi, P.;Brunori, M.;Derudas, D.;Ledda, A.;Gozzetti, A.;Cellini, C.;Malerba, L.;Mele, A.;Andriani, A.;Galimberti, S.;Mondello, P.;Pulini, S.;Coppetelli, U.;Fraticelli, P.;Olivieri, A.;Leoni, P.
通讯作者：
Leoni, P.