Talbot-Lau x-ray phase-contrast setup for fast scanning of large samples
Talbot-Lau x-ray phase-contrast setup for fast scanning of large samples
复制标题
DOI：
10.1038/s41598-018-38030-3
复制
发表时间：
2019-03-12
影响因子：
4.6
通讯作者：
Anton, Gisela
中科院分区：
文献类型：
--
作者：
Seifert, Maria;Ludwig, Veronika;Anton, Gisela
与传统的衰减 X 射线放射成像相比，X 射线 Talbot-Lau 技术提供了有关光束路径中物体的散射和折射特性的更多信息。因此，这些附加信息应该改进有关医疗应用和无损检测的诊断过程。然而，到目前为止，由于光栅制造工艺的原因，Talbot-Lau 成像仍存在光栅尺寸较小（直径 70 毫米）的问题。这导致大型物体成像的采集时间较长。缝合光栅是一种解决方案。另一种方法是扫描 Talbot-Lau 设置。在本出版物中，我们提出了一种紧凑且非常快速的扫描装置，可以对大样本进行成像。通过此设置，最大扫描速度可以达到 71.7 毫米/秒。分辨率可达到 4.1 线/毫米。视野范围为 17.5 x 150 cm2，无需复杂的对准程序。已经开发并提出了一种关于扫描方法的改进重建算法，该算法提高了机械不稳定性的鲁棒性。评估装置的分辨率与扫描速度的关系。使用离体人体膝盖作为高吸收人体样本的示例来演示设置成像质量。
Compared to conventional attenuation x-ray radiographic imaging, the x-ray Talbot-Lau technique provides further information about the scattering and the refractive properties of the object in the beam path. Hence, this additional information should improve the diagnostic process concerning medical applications and non-destructive testing. Nevertheless, until now, due to grating fabrication process, Talbot-Lau imaging suffers from small grating sizes (70 mm diameter). This leads to long acquisition times for imaging large objects. Stitching the gratings is one solution. Another one consists of scanning Talbot-Lau setups. In this publication, we present a compact and very fast scanning setup which enables imaging of large samples. With this setup a maximal scanning velocity of 71.7 mm/s is possible. A resolution of 4.1 lines/mm can be achieved. No complex alignment procedures are necessary while the field of view comprises 17.5 x 150 cm2. An improved reconstruction algorithm concerning the scanning approach, which increases robustness with respect to mechanical instabilities, has been developed and is presented. The resolution of the setup in dependence of the scanning velocity is evaluated. The setup imaging qualities are demonstrated using a human knee ex-vivo as an example for a high absorbing human sample.