Influence of age at menarche on forearm bone microstructure in healthy young women
Influence of age at menarche on forearm bone microstructure in healthy young women
复制标题
DOI：
10.1210/jc.2007-2644
复制
发表时间：
2008-07-01
影响因子：
5.8
通讯作者：
Rizzoli, Rene
中科院分区：
文献类型：
--
作者：
Chevalley, Thierry;Bonjour, Jean-Philippe;Rizzoli, Rene
背景：从青春期开始到达到峰值骨量的较短的雌激素暴露可能解释了为什么月经初潮晚是骨质疏松症的危险因素。在124名年龄为20.4 ± 0.6（SD）岁的健康女性中研究了月经初潮年龄（MENA）对峰值骨量、皮质骨和骨小梁显微结构的影响。在桡骨远端，通过双能X线吸收法测量面积骨密度（aBMD），通过高分辨率外周计算机断层扫描测量体积骨密度（BMD）和显微结构，包括：总骨密度、皮质骨密度和骨小梁体积骨密度和骨小梁分数;骨小梁数量、厚度和间距;皮质骨厚度（CTh）;和横截面积（CSA）。整个队列的平均aBMD T评分为轻度阳性。总桡骨（R = -0.21; P = 0.018）、骨干（R = -0.18; P = 0.043）和干骺端（R = -0.19; P = 0.031）的aBMD与MENA呈负相关。MENA大于中位数[LATER：14.0 +/- 0.7（+/- SD）年]的受试者在总桡骨（P = 0.026）、骨干（P = 0.042）和干骺端（P = 0.046）的aBMD低于MENA小于中位数（LARLIER：12.1 +/- 0.7年）的受试者。LATER与EARLIER相比，显示总体积BMD较低（315 +/- 54 vs. 341 +/- 56 mg HA/cm（3）; P = 0.010），皮质体积BMD（874 +/- 49 vs. 901 +/- 44 mg HA/cm（3）; P = 0.003）和CTh（774 +/- 170 vs. 849 +/- 191 μ m; P = 0.023）。CTh与CSA呈负相关（R = -0.46; P < 0.001）。在后来减少CTh与5%的增加CSA.Conclusions：在健康的年轻成年女性，平均MENA的1.9年的差异与较低的径向aBMD T评分，较低的CTh没有减少CSA，发现兼容较少的皮质内累积。这可以解释为什么月经初潮晚是前臂骨质疏松症的一个危险因素。
Background: Shorter estrogen exposure from puberty onset to peak bone mass attainment may explain how late menarche is a risk factor for osteoporosis. The influence of menarcheal age (MENA) on peak bone mass, cortical, and trabecular microstructure was studied in 124 healthy women aged 20.4 +/- 0.6 (SD) yr.Methods: At distal radius, areal bone mineral density (aBMD) was measured by dual-energy x-ray absorptiometry, and volumetric bone mineral density (BMD) and microstructure were measured by high-resolution peripheral computerized tomography, including: total, cortical, and trabecular volumetric BMD and fraction; trabecular number, thickness, and spacing; cortical thickness (CTh); and cross-sectional area (CSA).Results: Median MENA was 12.9 yr. Mean aBMD T score of the whole cohort was slightly positive. aBMD was inversely correlated to MENA for total radius (R = -0.21; P = 0.018), diaphysis (R = -0.18; P = 0.043), and metaphysis (R = -0.19; P = 0.031). Subjects with MENA more than the median [LATER: 14.0 +/- 0.7 (+/- SD) yr] had lower aBMD than those with MENA less than the median (EARLIER: 12.1 +/- 0.7 yr) in total radius (P = 0.026), diaphysis (P = 0.042), and metaphysis (P = 0.046). LATER vs. EARLIER displayed lower total volumetric BMD (315 +/- 54 vs. 341 +/- 56 mg HA/cm(3); P = 0.010), cortical volumetric BMD (874 +/- 49 vs. 901 +/- 44 mg HA/cm(3); P = 0.003), and CTh (774 +/- 170 vs. 849 +/- 191 mu m; P = 0.023). CTh was inversely related to CSA (R = -0.46; P < 0.001). In LATER reduced CTh was associated with 5% increased CSA.Conclusions: In healthy young adult women, a 1.9-yr difference in mean MENA was associated with lower radial aBMD T score, lower CTh without reduced CSA, a finding compatible with less endocortical accrual. It may explain how late menarche is a risk factor for forearm osteoporosis.