Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)
Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina)
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在 SIVmac239 感染的北方猪尾猕猴 (Macaca leonina) 中，良好的肠道完整性和有限的微生物易位与较低的免疫激活有关。
DOI：
10.24272/j.issn.2095-8137.2019.047
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发表时间：
2019-11-18
影响因子：
4.9
通讯作者：
Zheng，Yong-Tang
中科院分区：
文献类型：
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作者：
Zhang，Ming-Xu;Song，Tian-Zhang;Zheng，Yong-Tang
微生物易位是HIV/SIV感染中全身免疫激活的原因。在本研究中，我们发现猴（北方猪尾猕猴，NPMs）的CD 8 + T细胞活化水平低于猕猴（中国恒河猴，ChRM）在SIVmac 239感染。此外，血浆LPS结合蛋白和可溶性CD 14的水平在NPMs低于ChRM。与ChRM相比，SIV感染的NPM具有较低的Chiu评分，代表相对正常的肠粘膜。此外，在感染或未感染的NPM中均未观察到对回肠或结肠上皮屏障的明显损伤，这与ChRM中发现的不同。此外，在感染或未感染的NPM的结肠或回肠中未检测到显著的微生物易位（大肠杆菌），这再次不同于在ChRM中观察到的。总之，NPM在SIV感染期间保持了上级肠道完整性和有限的微生物移位，这可能有助于其与ChRM相比较低的免疫激活。
Microbial translocation is a cause of systemic immune activation in HIV/SIV infection. In the present study, we found a lower CD8+ T cell activation level in Macaca leonina (northern pig-tailed macaques, NPMs) than in Macaca mulatta (Chinese rhesus macaques, ChRMs) during SIVmac239 infection. Furthermore, the levels of plasma LPS-binding protein and soluble CD14 in NPMs were lower than those in ChRMs. Compared with ChRMs, SIV-infected NPMs had lower Chiu scores, representing relatively normal intestinal mucosa. In addition, no obvious damage to the ileum or colon epithelial barrier was observed in either infected or uninfected NPMs, which differed to that found in ChRMs. Furthermore, no significant microbial translocation ( Escherichia coli) was detected in the colon or ileum of infected or uninfected NPMs, which again differed to that observed in ChRMs. In conclusion, NPMs retained superior intestinal integrity and limited microbial translocation during SIV infection, which may contribute to their lower immune activation compared with ChRMs.