Relationships between Cerebral Blood Flow and IQ in Typically Developing Children and Adolescents.
Relationships between Cerebral Blood Flow and IQ in Typically Developing Children and Adolescents.
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DOI：
10.17791/jcs.2011.12.2.151
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发表时间：
2011
影响因子：
0.1
通讯作者：
Wang DJ
中科院分区：
文献类型：
--
作者：
Kilroy E;Liu CY;Yan L;Kim YC;Dapretto M;Mendez MF;Wang DJ
本研究的目的是探讨儿童和青少年中智商（IQ）与通过动脉自旋标记（ASL）测量的脑血流（CBF）之间的关系。对39名7至17岁的健康参与者使用ASL收集灌注磁共振成像数据。采用韦氏简版智力量表测定IQ分数。应用多元回归揭示CBF和IQ分数之间的相关性，并考虑年龄、性别和全脑平均CBF。进行基于体素的形态测量学（VBM）分析（其测量区域皮质体积）作为对照。进一步对CBF数据进行回归分析，并调整区域灰质密度（GMD）。CBF和IQ分数之间的正相关主要见于膝下/前扣带回、右侧眶额叶、颞上叶和右侧顶下叶区域。CBF和IQ之间的负相关主要在双侧颞后叶区域观察到。在调整区域GMD后，膝下/前扣带回皮质、右侧眶额叶、颞上叶区域和左侧岛叶中CBF和IQ之间的相关性仍然显著。这些发现支持智力的顶 - 额整合理论，特别是膝下/前扣带回皮质在与智力相关的神经网络中的作用。本研究还证明了除结构形态测量指标外，CBF在评估脑 - 行为关系方面的独特价值。
The objective of this study was to explore the relationships between IQ and cerebral blood flow (CBF) measured by arterial spin labeling (ASL) in children and adolescents. ASL was used to collect perfusion MRI data on 39 healthy participants aged 7 to 17. The Wechsler Abbreviated Intelligence Scale was administered to determine IQ scores. Multivariate regression was applied to reveal correlations between CBF and IQ scores, accounting for age, sex and global mean CBF. Voxel Based Morphometry (VBM) analysis, which measures regional cortical volume, was performed as a control. Regression analyses were further performed on CBF data with adjustment of regional gray matter density (GMD). A positive correlation between CBF and IQ scores was primarily seen in the subgenual/anterior cingulate, right orbitofrontal, superior temporal and right inferior parietal regions. An inverse relationship between CBF and IQ was mainly observed in bilateral posterior temporal regions. After adjusting for regional GMD, the correlations between CBF and IQ in the subgenual/anterior cingulate cortex, right orbitofrontal, superior temporal regions and left insula remained significant. These findings support the Parieto-Frontal Integration Theory of intelligence, especially the role of the subgenual/anterior cingulate cortex in the neural networks associated with intelligence. The present study also demonstrates the unique value of CBF in assessing brain-behavior relationships, in addition to structural morphometric measures.