The emerging role of long non-coding RNAs in HIV infection.
The emerging role of long non-coding RNAs in HIV infection.
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DOI：
10.1016/j.virusres.2015.07.023
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发表时间：
2016-01-02
期刊：
影响因子：
5
通讯作者：
Saayman SM
中科院分区：
文献类型：
--
作者：
Lazar DC;Morris KV;Saayman SM
长链非编码RNA（lncRNA）的发现以及它们影响不同疾病状态的机制的阐明，为研究人员提供了对各种疾病途径的更好理解。此外，lncRNA本身既是独特的诊断生物标志物，也是开发新疗法的新靶点。在这里，我们将探索与人类免疫缺陷病毒（HIV）感染相关的非编码RNA的复杂网络。来自人类宿主和HIV本身的非编码RNA正在成为重要的调控元件。我们在这里讨论了小的和长的非编码RNA影响病毒复制，发病机制和疾病进展的各种机制。由于缺乏有效的疫苗或治疗艾滋病毒和目前的流行病的规模，更深入地了解非编码RNA和艾滋病毒之间的复杂相互作用将支持开发创新的策略，用于治疗艾滋病毒/获得性免疫缺陷疾病（艾滋病）。
The discovery of long non-coding RNAs (lncRNAs) and the elucidation of the mechanisms by which they affect different disease states is providing researchers with a better understanding of a wide array of disease pathways. Moreover, lncRNAs are presenting themselves as both unique diagnostic biomarkers as well as novel targets against which to develop new therapeutics. Here we will explore the intricate network of non-coding RNAs associated with infection by the human immunodeficiency virus (HIV). Non-coding RNAs derived from both the human host as well as those from HIV itself are emerging as important regulatory elements. We discuss here the various mechanisms through which both small and long non-coding RNAs impact viral replication, pathogenesis and disease progression. Given the lack of an effective vaccine or cure for HIV and the scale of the current pandemic, a deeper understanding of the complex interplay between non-coding RNAs and HIV will support the development of innovative strategies for the treatment of HIV/acquired immunodeficiency disease (AIDS).