Antigenic relationships among the coronaviruses of man and between human and animal coronaviruses.
Antigenic relationships among the coronaviruses of man and between human and animal coronaviruses.
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人类冠状病毒之间以及人类和动物冠状病毒之间的抗原关系。
DOI：
10.4049/jimmunol.102.5.1109
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发表时间：
1969
影响因子：
4.4
通讯作者：
R. Chanock
中科院分区：
文献类型：
--
作者：
Kenneth D. Mcintosh;A. Kapikian;Kathleen A. Hardison;J. Hartley;R. Chanock
本文对7株器官培养人冠状病毒、1株组织培养人冠状病毒（229 E）、几株小鼠肝炎病毒（MHV）和1株传染性支气管炎病毒（IBV）进行了抗原性比较。通过使用中和、补体结合和荧光抗体试验，表明毒株IBV-42与人和鼠病毒无关，毒株229 E与检测的鼠或其他人毒株关系很小（如果有的话）。此外，三个器官培养生长的病毒，其中两个已适应在乳鼠中生长，被证明是抗原相关的几个株MHV。其余4株人源菌株具有异质性和不明确的抗原特征。
Antigenic comparison of seven organ culture-grown human coronavirus strains, one tissue culture-grown human strain (229E), several strains of mouse hepatitis virus (MHV) and one strain of infectious bronchitis virus (IBV) was made. With the use of neutralization, complement fixation and fluorescent antibody tests, it was shown that strain IBV-42 was unrelated to the human and murine viruses and that strain 229E bore little, if any, relation to the murine or other human strains tested. In addition, three of the organ culture grown viruses, two of which have been adapted to growth in suckling mice, were shown to be antigenically related to several strains of MHV. The four remaining human strains possessed heterogeneous and poorly defined antigenic characteristics.