Patterns of DNA methylation as an indicator of biological aging: State of the science and future directions in precision health promotion
Patterns of DNA methylation as an indicator of biological aging: State of the science and future directions in precision health promotion
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DOI：
10.1016/j.outlook.2019.05.006
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发表时间：
2019-07-01
期刊：
影响因子：
4.3
通讯作者：
Anderson, Cindy M.
中科院分区：
文献类型：
--
作者：
Gillespie, Shannon L.;Hardy, Lynda R.;Anderson, Cindy M.
背景：大量文献表明，相同实足年龄的个体在生物年龄上表现出显着差异。目的：本文的目的是回顾有关通过 DNA 甲基化估计表观遗传年龄的文献，涉及在 DNA 中添加或去除甲基基团，从而在不改变 DNA 序列的情况下改变基因表达。方法：这篇科学文献综述总结了表观遗传年龄测定和衰老算法应用的当前方法。研究结果：许多算法使用 DNA 甲基化标记估计表观遗传年龄，主要是在成年人中。算法应用的重点是确定疾病和死亡风险的预测价值，并确定年龄加速的前因。几项研究已纳入表观遗传年龄来评估干预效果。讨论：随着研究界不断完善衰老算法，可能有机会从精准健康的角度促进健康。
Background: A rapidly expanding literature suggests that individuals of the same chronological age show significant variation in biological age.Purpose: The purpose of this article is to review the literature surrounding epigenetic age as estimated by DNA methylation, involving the addition or removal of methyl groups to DNA that can alter gene expression without changing the DNA sequence.Methods: This state of the science literature review summarizes current approaches in epigenetic age determination and applications of aging algorithms.Findings: A number of algorithms estimate epigenetic age using DNA methylation markers, primarily among adults. Algorithm application has focused on determining predictive value for risk of disease and death and identifying antecedents to age acceleration. Several studies have incorporated epigenetic age to evaluate intervention effectiveness.Discussion: As the research community continues to refine aging algorithms, there may be opportunity to promote health from a precision health perspective.