Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma
Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma
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DOI：
10.1038/onc.2010.305
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发表时间：
2010-10-01
期刊：
影响因子：
8
通讯作者：
Wu, X.
中科院分区：
文献类型：
--
作者：
Hildebrandt, M. A. T.;Gu, J.;Wu, X.
透明细胞肾细胞癌（ccRCC）的长期预后会因转移性复发的发展而发生显著改变。然而，很少有指标可以预测哪些患者会复发。microRNA调节许多细胞过程，并已被证明与癌症的发展和复发有关。最近，已经表明microRNA基因可以在癌症中被表观遗传修饰，导致具有肿瘤抑制功能的microRNA基因的异常沉默。在这项研究中，我们发现两个编码hsa-miR-9的基因在ccRCC肿瘤中与邻近的正常组织相比显著高甲基化（P值
The long-term prognosis for clear cell renal cell carcinoma (ccRCC) is dramatically altered by the development of metastatic recurrence. However, there are very few indicators that can predict which patient will develop a recurrence. MicroRNAs regulate many cellular processes and have been shown to be associated with cancer development and recurrence. More recently it has been shown that microRNA genes can be epigenetically modified in cancer, resulting in aberrant silencing of microRNA genes with tumor suppressor functions. In this study, we show that two genes encoding for hsa-miR-9 are significantly hypermethylated in ccRCC tumors compared with adjacent normal tissues (P-value