Patterns of memory impairment in bipolar disorder and unipolar major depression
Patterns of memory impairment in bipolar disorder and unipolar major depression
复制标题
DOI：
10.1016/j.psychres.2005.08.010
复制
发表时间：
2006-06-15
影响因子：
11.3
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Bearden, Carrie E.;Glahn, David C.;Soares, Jair C.
众所周知，单相和双相抑郁会对学习和记忆过程产生有害影响。然而，很少对具有相似病史的双相情感障碍和单相情感障碍患者进行比较，并且对损伤的预测因素尚不清楚。患有单相重性抑郁症（UP，n = 30）和双相情感障碍（BP，n = 30）的成人门诊患者，根据疾病持续时间和抑郁症状严重程度进行分组（16％临床缓解，42％部分缓解，42％抑郁），以及30名人口统计学匹配的对照者完成了一般认知功能和陈述性记忆的测量。尽管一般智力能力相当，但 BP 和 UP 患者与健康对照组相比表现出显着的记忆缺陷。在两个患者组中都观察到了类似的缺陷特征，包括较差的言语回忆和识别能力。损伤并不是战略处理缺陷或快速遗忘的次要因素。尽管抑郁严重程度与神经认知表现无关，但住院次数和情绪障碍家族史显着影响 BP 患者的记忆功能，但对 UP 患者的记忆功能没有影响。结果表明，BP 和 UP 患者的记忆损害模式在性质上相似，与原发性编码缺陷一致。这些损伤似乎并不是继发于临床状态，而是表明涉及内侧颞叶功能障碍的类似潜在病理生理学。 (c) 2005 Elsevier Ireland Ltd. 保留所有权利。
Unipolar and bipolar depression are known to exert detrimental effects on learning and memory processes. However, few comparisons have been undertaken between bipolar and unipolar patients with comparable illness histories, and predictors of impairment are not well understood. Adult outpatients with unipolar major depressive illness (UP, n = 30) and bipolar disorder (BP, n = 30), group-matched for illness duration and severity of depressive symptomatology (16% clinically remitted, 42% partially remitted, 42% depressed), and 30 demographically matched controls completed measures of general cognitive functioning and declarative memory. Despite comparable general intellectual abilities, BP and UP patients exhibited significant memory deficits relative to healthy controls. A similar deficit profile was observed in both patient groups, involving poorer verbal recall and recognition. Impairments were not secondary to strategic processing deficits or rapid forgetting. Although depression severity was not associated with neurocognitive performance, number of hospitalizations and family history of mood disorder significantly affected memory function in BP, but not UP, patients. Results suggest qualitatively similar patterns of memory impairment in BP and UP patients, consistent with a primary encoding deficit. These impairments do not appear to be secondary to clinical state, but rather suggest a similar underlying pathophysiology involving medial temporal dysfunction. (c) 2005 Elsevier Ireland Ltd. All rights reserved.