Natural compounds as regulators of the cancer cell metabolism.
Natural compounds as regulators of the cancer cell metabolism.
复制标题
DOI：
10.1155/2013/639401
复制
发表时间：
2013
影响因子：
--
通讯作者：
Diederich M
中科院分区：
文献类型：
--
作者：
Cerella C;Radogna F;Dicato M;Diederich M
尽管代谢改变是一种“古老的”生理机制，但直到最近，它的靶向才成为一种有趣的治疗策略，到目前为止，它被认为是癌症的一个新兴标志。然而，很少有化合物作为细胞代谢的潜在调节剂正在研究中。候选药物应对癌细胞表现出选择性作用而无副作用。这种理想的有利条件将完美地与新的抗癌疗法和化学预防策略的要求重叠。大自然代表了一个很大程度上尚未开发的具有治疗潜力的生物活性分子的来源。这些化合物中有许多已经被证明具有多种抗癌活性。它们中的许多被饮食吸收，因此与新合成的化合物相比，在耐受性和生物利用度方面具有已知的概况。癌症中最具治疗针对性的异常（即细胞增殖、存活和迁移）的介质与代谢机制之间的重要交叉对话的发现，允许预测许多归因于许多天然化合物的抗癌活性可能部分归因于它们调节代谢途径的能力的可能性。在这篇综述中，我们试图概述目前已知的天然化合物作为癌细胞代谢调节剂的潜力。
Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism.