Boron neutron capture therapy for urological cancers
Boron neutron capture therapy for urological cancers
复制标题
硼中子捕获疗法治疗泌尿系统癌症
DOI：
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发表时间：
2022
影响因子：
2.6
通讯作者：
R. Shiroki
中科院分区：
文献类型：
--
作者：
K. Takahara;S. Miyatake;H. Azuma;R. Shiroki
硼中子俘获疗法是基于非放射性同位素硼- 10与低能热中子或高能超热中子之间的核反应，产生高线性能量转移的α粒子和反冲锂核（7Li），选择性地破坏肿瘤细胞中的DNA螺旋。硼中子俘获治疗是一种新兴的治疗方法，旨在提高各种恶性肿瘤的传统治疗的治疗率，临床上已在多种疾病中进行了研究，包括胶质母细胞瘤、头颈癌、皮肤黑色素瘤、肝细胞癌、肺癌和乳腺外佩吉特病。然而，除出现在阴囊至阴茎区域的生殖器乳腺外佩吉特病外，硼中子俘获疗法尚未在泌尿系统癌症中进行临床应用。在这篇综述中，我们旨在提供硼中子俘获治疗患者的最新临床文献总结，并重点讨论硼中子俘获治疗泌尿系统癌症的未来前景。
Boron neutron capture therapy is based on a nuclear reaction between the nonradioactive isotope boron‐10 and either low‐energy thermal neutrons or high‐energy epithermal neutrons, which generate high linear energy transfer α particles and a recoiled lithium nucleus (7Li) that selectively destroys the DNA helix in tumor cells. Boron neutron capture therapy is an emerging procedure aimed at improving the therapeutic ratio for the traditional treatment of various malignancies, which has been studied clinically in a variety of diseases, including glioblastoma, head and neck cancer, cutaneous melanoma, hepatocellular carcinoma, lung cancer, and extramammary Paget’s disease. However, boron neutron capture therapy has not been clinically performed for urological cancers, excluding genital extramammary Paget's disease that appeared at the scrotum to penis area. In this review, we aimed to provide an updated summary of the current clinical literature of patients treated with boron neutron capture therapy and to focus on the future prospects of boron neutron capture therapy for urological cancers.
影响因子：
2.6
作者：
Skold, K.;Gorlia, T.;Hopewell, J. W.
通讯作者：
Hopewell, J. W.
影响因子：
11.2
作者：
Hillier SM;Maresca KP;Femia FJ;Marquis JC;Foss CA;Nguyen N;Zimmerman CN;Barrett JA;Eckelman WC;Pomper MG;Joyal JL;Babich JW
通讯作者：
Babich JW