Wearable Biosensors to Detect Physiologic Change During Opioid Use
Wearable Biosensors to Detect Physiologic Change During Opioid Use
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DOI：
10.1007/s13181-016-0557-5
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发表时间：
2016-09-01
影响因子：
2.9
通讯作者：
Boyer, Edward W.
中科院分区：
文献类型：
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作者：
Carreiro, Stephanie;Wittbold, Kelley;Boyer, Edward W.
阿片类镇痛药的使用是美国发病率和死亡率的主要原因，但有效的治疗方案检测复发的能力有限。目前的药物检测方法的实用性往往受到限制，由于其回顾性和主观性。穿戴式生物传感器有可能提高检测复发提供客观的，真实的时间的生理数据阿片类药物的使用，可用于治疗临床医生，以增加behavioral interventions.Methods三十急诊科（艾德）的患者谁被规定静脉注射阿片类药物治疗急性疼痛被招募到佩戴腕带生物传感器。该生物传感器测量皮肤电活动，皮肤温度和运动数据，这是记录之前和之后静脉注射阿片类药物。希尔伯特变换分析结合配对t检验被用来比较生物传感器数据A）内的主题，阿片类药物给药前和给药后; B）之间的主题，根据手的优势，性别，和阿片类药物使用history.Results内的主题，一个显着减少运动和皮肤温度的增加一致检测到阿片类药物给药后的生物传感器。没有一致地检测到皮肤电活动的显著变化。在受试者之间，生物特征变化随阿片类药物使用史的水平（重度与非重度使用者）而变化，但不随性别或阿片类药物类型而变化。具体而言，重度使用者表现出更大的减少，在短幅度的运动（即坐立不安的动作）相比，non-heavy users. Conclusions穿戴式生物传感器显示一致的生理模式后，艾德阿片类药物管理和模式之间的差异，重度和非重度阿片类药物用户。生物传感器在药物成瘾治疗和疼痛管理方面的潜在应用值得进一步研究。
Introduction Opioid analgesic use is a major cause of morbidity and mortality in the US, yet effective treatment programs have a limited ability to detect relapse. The utility of current drug detection methods is often restricted due to their retrospective and subjective nature. Wearable biosensors have the potential to improve detection of relapse by providing objective, real time physiologic data on opioid use that can be used by treating clinicians to augment behavioral interventions.Methods Thirty emergency department (ED) patients who were prescribed intravenous opioid medication for acute pain were recruited to wear a wristband biosensor. The biosensor measured electrodermal activity, skin temperature and locomotion data, which was recorded before and after intravenous opioid administration. Hilbert transform analyses combined with paired t-tests were used to compare the biosensor data A) within subjects, before and after administration of opioids; B) between subjects, based on hand dominance, gender, and opioid use history.Results Within subjects, a significant decrease in locomotion and increase in skin temperature were consistently detected by the biosensors after opioid administration. A significant change in electrodermal activity was not consistently detected. Between subjects, biometric changes varied with level of opioid use history (heavy vs. nonheavy users), but did not vary with gender or type of opioid. Specifically, heavy users demonstrated a greater decrease in short amplitude movements (i.e. fidgeting movements) compared to non-heavy users.Conclusion A wearable biosensor showed a consistent physiologic pattern after ED opioid administration and differences between patterns of heavy and non-heavy opioid users were noted. Potential applications of biosensors to drug addiction treatment and pain management should be studied further.