Medroxyprogesterone therapy for sexual precocity in girls.
Medroxyprogesterone therapy for sexual precocity in girls.
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甲羟孕酮治疗女孩性早熟。
DOI：
10.1001/archpedi.1981.02130290041015
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发表时间：
1981
影响因子：
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通讯作者：
P. A. Lee
中科院分区：
文献类型：
--
作者：
P. A. Lee
对13名接受醋酸甲羟孕酮肌内注射治疗性早熟的女孩进行的评估表明，这种药物对生长、骨骼成熟或成年身高没有影响。在治疗期间（平均持续时间，3.6年），月经受到抑制，乳房大小最初消退，但乳房发育和公共毛发发育在长期治疗期间进展。停止治疗后月经恢复延迟的程度与治疗持续时间和药物剂量有关。
An evaluation of 13 girls who had been treated intramuscularly with medroxyprogesterone acetate for sexual precocity showed that this drug has no effect on growth, skeletal maturation, or adult height. During treatment (mean duration, 3.6 years), menstruation was suppressed and breast size initially regressed, but breast development and public hair development progressed during long-term therapy. The extent of delay in resumption of menses after cessation of therapy was related both to duration of treatment and dosage of the drug.