Discovertebral (Andersson) lesions of the spine in ankylosing spondylitis revisited.

Discovertebral (Andersson) lesions of the spine in ankylosing spondylitis revisited.
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DOI:
10.1007/s10067-009-1151-x
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发表时间:
2009-08
影响因子:
3.4
通讯作者:
Van Royen, Barend J.
Van Royen, Barend J.
中科院分区:
医学3区
文献类型:
--
作者:
Bron, Johannes L.;de Vries, Mirjam K.;Snieders, Marieke N.;van der Horst-Bruinsma, Irene E.;Van Royen, Barend J.

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强直性脊柱炎(AS)患者的一个众所周知的并发症是脊柱局部脊椎或椎间盘病变的发展,安德森于1937年首次描述了这一点。从那时起,文献中使用了许多不同的术语来指代这些局限性的脊柱病变,包括同名的Andersson病变(AL)。使用不同的术语反映了关于AL确切病因的持续辩论。在目前的研究中,我们对文献进行了广泛的回顾,以使治疗医生之间在病因学、诊断和管理方面的沟通保持一致。AL可能是由于炎症或(应力性)骨折造成的。没有证据表明有传染性来源。不管确切的病因是什么,都存在一个最终的共同途径,在这个途径中,机械应力阻止了病变融合,并引发了假关节的发展。AL的诊断建立在传统的放射检查基础上,但计算机断层扫描和磁共振成像都提供了额外的信息。没有诊断性活组织检查的指征。手术内固定和融合被认为是保守治疗不能解决的症状性急性白血病的主要治疗方法。我们建议使用术语Andersson病变来描述AS患者的这些脊柱病变。
A well-known complication in patients with ankylosing spondylitis (AS) is the development of localised vertebral or discovertebral lesions of the spine, which was first described by Andersson in 1937. Since then, many different terms are used in literature to refer to these localised lesions of the spine, including the eponym ‘Andersson lesion’ (AL). The use of different terms reflects an ongoing debate on the exact aetiology of the AL. In the current study, we performed an extensive review of the literature in order to align communication on aetiology, diagnosis and management between treating physicians. AL may result from inflammation or (stress-) fractures of the complete ankylosed spine. There is no evidence for an infectious origin. Regardless of the exact aetiology, a final common pathway exists, in which mechanical stresses prevent the lesion from fusion and provoke the development of pseudarthrosis. The diagnosis of AL is established on conventional radiography, but computed tomography and magnetic resonance imaging both provide additional information. There is no indication for a diagnostic biopsy. Surgical instrumentation and fusion is considered the principle management in symptomatic AL that fails to resolve from a conservative treatment. We advise to use the term Andersson lesion for these spinal lesions in patients with AS.
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