Fundus autofluorescence in multifocal choroiditis and panuveitis
Fundus autofluorescence in multifocal choroiditis and panuveitis
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DOI：
10.1016/j.ajo.2008.01.008
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发表时间：
2008-05-01
影响因子：
4.2
通讯作者：
Spaide, Richard F.
中科院分区：
文献类型：
--
作者：
Haen, Sebastian P.;Spaide, Richard F.
目的：研究与多灶性脉络膜炎和泛发性脉络膜炎(MCP)相关的自发荧光表现，这种疾病具有显著的潜在影响视网膜色素上皮(RPE)。设计：观察性病例系列。方法：这是一项视网膜转诊实践中连续检查的MCP患者的回顾。所有患者均接受眼底摄影、血管造影和自体荧光摄影检查，其中激发滤光片的带通波长为585 nm，屏障滤光片的带通波长为615~715 nm。结果：对18例患者的36只眼进行了评估。平均症状持续时间86.2个月，平均视力20/50。36只眼中23只眼有脉络膜新生血管(CNV)。脉络膜视网膜低自体荧光斑点通常为125微米，但并非总是，临床上与彩色眼底照相可见的被打出的疤痕明显相关。脉络膜视网膜弱自身荧光点小于125微米，可能有数百个，通常在彩色眼底照相中看不到。所有彩色眼底照相可见的脉络膜视网膜瘢痕在自发荧光照相中均可见。在随访期间，许多患者出现了新的临床明显的脉络膜视网膜瘢痕，这在早期的自发荧光照片中是有先兆的。CNV有一个高自体荧光的边界，因此很容易看到。结论：MCP患者比其他成像手段怀疑的患者更广泛地累及RPE。自体荧光摄影以非侵入性方式提供有关炎性损伤和继发性CNV的信息。
PURPOSE: To investigate the autofluorescence findings associated with multifocal choroiditis and panuveits (MCP), a condition that has marked potential to affect the retinal pigment epithelium (RPE).DESIGN: Observational case series.METHODS: This is a retrospective review of consecutive patients with MCP examined in a retinal referral practice. Each patient was given a comprehensive examination including fundus photographs, angiographic studies, and autofluorescence photography with an excitation filter with the bandpass wavelengths of 535 to 585 nm and a barrier filter with a bandpass of 615 to 715 nm. Integrative analysis was performed of the ocular imaging to ascertain abnormalities caused by the disease.RESULTS: Thirty,six eyes of 18 consecutive patients were evaluated. The mean duration of symptoms was 86.2 months and the mean visual acuity was 20/50. Of the 36 eyes, 23 had choroidal neovascularization (CNV). Chorioretinal hypoautofluorescent spots >= 125 microns usually, but not always, had the clinically evident correlate of a punched-out scar visible by color fundus photography. Chorioretinal hypoautofluorescent spots less than 125 microns, which could number in the hundreds, typically were not visible by color fundus photography. All chorioretinal scars visible by color fundus photography were visible by autofluorescence photography. During follow-up many patients developed new clinically evident chorioretinal scars, which were presaged in earlier autofluorescence photographs. CNV had a hyper-autofluorescent boundary, making it readily visible.CONCLUSIONS: Patients with MCP have much more widespread involvement of the RPE than would he suspected by other means of imaging. Autofluorescence photography supplies information about inflammatory damage and secondary CNV in a noninvasive manner.