Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data
Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data
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DOI：
10.1523/jneurosci.6207-10.2011
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发表时间：
2011-06-15
影响因子：
5.3
通讯作者：
Iannetti, Gian Domenico
中科院分区：
文献类型：
--
作者：
Liang, Meng;Mouraux, Andre;Iannetti, Gian Domenico
一些研究表明，在高等灵长类动物中，伤害性躯体感觉信息在初级（S1）和次级（S2）躯体感觉皮层中并行处理，而非伤害性躯体感觉输入则从S1到S2连续处理。然而，也有证据表明，伤害性和非伤害性躯体感觉输入在S1和S2中平行处理。在这里，我们的目的是澄清是否在S1和S2的伤害性和非伤害性躯体感觉处理的层次组织在人类不同。为了解决这个问题，我们应用动态因果模型和贝叶斯模型选择功能磁共振成像（fMRI）的数据收集在人类的伤害性和非伤害性躯体感觉传入的选择性刺激。这种新的方法使我们能够探索伤害性和非伤害性体感信息如何在体感系统中流动。我们发现，伤害性和非伤害性躯体感觉刺激引起的神经活动最好的解释模型中，在S1和S2的功能磁共振成像反应依赖于直接的丘脑皮质投射。这些观察结果表明，在人类中，伤害性和非伤害性信息在S1和S2中平行处理。
Several studies have suggested that, in higher primates, nociceptive somatosensory information is processed in parallel in the primary (S1) and secondary (S2) somatosensory cortices, whereas non-nociceptive somatosensory input is processed serially from S1 to S2. However, evidence suggesting that both nociceptive and non-nociceptive somatosensory inputs are processed in parallel in S1 and S2 also exists. Here, we aimed to clarify whether or not the hierarchical organization of nociceptive and non-nociceptive somatosensory processing in S1 and S2 differs in humans. To address this question, we applied dynamic causal modeling and Bayesian model selection to functional magnetic resonance imaging (fMRI) data collected during the selective stimulation of nociceptive and non-nociceptive somatosensory afferents in humans. This novel approach allowed us to explore how nociceptive and non-nociceptive somatosensory information flows within the somatosensory system. We found that the neural activities elicited by both nociceptive and non-nociceptive somatosensory stimuli are best explained by models in which the fMRI responses in both S1 and S2 depend on direct thalamocortical projections. These observations indicate that, in humans, both nociceptive and non-nociceptive information are processed in parallel in S1 and S2.