The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition
The miR-132/212 locus: a complex regulator of neuronal plasticity, gene expression and cognition
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DOI：
10.14800/rd.1375
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发表时间：
2016-08
期刊：
影响因子：
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通讯作者：
Sydney Aten;Katelin F. Hansen;K. Hoyt;K. Obrietan
中科院分区：
文献类型：
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作者：
Sydney Aten;Katelin F. Hansen;K. Hoyt;K. Obrietan
microRNA （miRNA）类小（通常为22-24 nt）非编码RNA影响哺乳动物中枢神经系统（CNS）的广泛生理过程。通过作为mRNA翻译和稳定性的有效调节因子，mirna微调了在复杂认知过程（包括学习和记忆）中起关键作用的众多基因的表达。值得注意的是，在中枢神经系统中，mirna可以以诱导的、细胞类型特异性的方式表达。在这里，我们简要概述了miR-132/212基因位点在中枢神经系统前脑回路中的表达和功能作用，然后讨论了最近发表的一篇文章，该文章探讨了miR-132和miR-212对认知和转录组调控的贡献。我们还讨论了突触活动调节miR-132/212表达的机制，miR-132和miR-212如何影响神经元可塑性，以及这两种mirna的失调如何导致认知障碍的发展。
The microRNA (miRNA) class of small (typically 22–24 nt) non-coding RNA affects a wide range of physiological processes in the mammalian central nervous system (CNS). By acting as potent regulators of mRNA translation and stability, miRNAs fine-tune the expression of a multitude of genes that play critical roles in complex cognitive processes, including learning and memory. Of note, within the CNS, miRNAs can be expressed in an inducible, and cell-type specific manner. Here, we provide a brief overview of the expression and functional effects of the miR-132/212 gene locus in forebrain circuits of the CNS, and then discuss a recent publication that explored the contributions of miR-132 and miR-212 to cognition and to transcriptome regulation. We also discuss mechanisms by which synaptic activity regulates miR-132/212 expression, how miR-132 and miR-212 affect neuronal plasticity, and how the dysregulation of these two miRNAs could contribute to the development of cognitive impairments.