Interleukin-6 in surgery, trauma, and critical care part II: clinical implications.
Interleukin-6 in surgery, trauma, and critical care part II: clinical implications.
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DOI：
10.1177/0885066610384188
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发表时间：
2011-03
影响因子：
3.1
通讯作者：
Kulaylat M
中科院分区：
文献类型：
--
作者：
Jawa RS;Anillo S;Huntoon K;Baumann H;Kulaylat M
多种细胞因子在炎症反应中发挥作用。白细胞介素-6（IL-6）型细胞因子响应于组织损伤或炎性刺激而释放，并局部和全身作用以产生多种生理反应。白细胞介素-6浓度在手术、创伤和危重病后升高。IL-6升高的幅度与组织创伤/损伤严重程度的程度相关。此外，IL-6升高与不良结局之间存在相关性。白细胞介素-6水平也可用于对患者进行分层以进行治疗干预。
A variety of cytokines play a role in the inflammatory response. Interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus, and act locally and systemically to generate a variety of physiologic responses. Interleukin-6 concentrations are elevated after surgery, trauma, and critical illness. The magnitude of IL-6 elevation correlates with the extent of tissue trauma/injury severity. Furthermore, there is an association between IL-6 elevation and adverse outcome. Interleukin-6 levels can also be used to stratify patients for therapeutic intervention.