The Living Scar--Cardiac Fibroblasts and the Injured Heart.
The Living Scar--Cardiac Fibroblasts and the Injured Heart.
复制标题
DOI：
10.1016/j.molmed.2015.12.006
复制
发表时间：
2016-02
影响因子：
13.6
通讯作者：
Markwald R
中科院分区：
文献类型：
--
作者：
Rog-Zielinska EA;Norris RA;Kohl P;Markwald R
心脏瘢痕，通常被认为是“死”组织，是非常有活力的，具有异细胞活性，确保心脏损伤后结构和机械完整性的维持。为了形成瘢痕，非肌细胞如成纤维细胞增殖并从心内和心外来源募集。成纤维细胞执行重要的自分泌和旁分泌信号功能。它们还与其他细胞建立机械连接，并且越来越明显地建立电连接。虽然成纤维细胞以前被认为只是作为电绝缘体，但它们可以相互电连接，并且在某些情况下，与其他细胞，包括心肌细胞。更好地了解这些相互作用将有助于靶向瘢痕结构和功能，并促进旨在改变瘢痕性质以使患者受益的新疗法的开发。这篇综述探讨了心脏成纤维细胞整合的现有见解和最新概念，并强调了利用其作用来优化心脏损伤（如梗死）和治疗干预（如消融）后的瘢痕功能的潜在途径。
Cardiac scars, often perceived as “dead” tissue, are very much alive, with heterocellular activity ensuring the maintenance of structural and mechanical integrity following heart injury. To form a scar, non-myocytes such as fibroblasts, proliferate and are recruited from intra- and extra-cardiac sources. Fibroblasts perform important autocrine and paracrine signalling functions. They also establish mechanical and, as is increasingly evident, electrical junctions with other cells. While fibroblasts were previously thought to act simply as electrical insulators, they may be electrically connected among themselves and, under certain circumstances, to other cells, including cardiomyocytes. A better understanding of these interactions will help target scar structure and function and facilitate the development of novel therapies aimed at modifying scar properties for patient benefit. This review explores available insight and recent concepts on fibroblast integration in the heart, and highlights potential avenues for harnessing their roles to optimise scar function following heart injury such as infarction, and therapeutic interventions such as ablation.