Concentrations of polyhrominated diphenyl ethers, polychlorinated biphenyls, and polychlorobiphenylols in serum from pregnant faroese women and their children 7 years later
Concentrations of polyhrominated diphenyl ethers, polychlorinated biphenyls, and polychlorobiphenylols in serum from pregnant faroese women and their children 7 years later
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DOI：
10.1021/es0513032
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发表时间：
2005-12-15
影响因子：
11.4
通讯作者：
Bergmant, Å
中科院分区：
文献类型：
--
作者：
Fängström, B;Hovander, L;Bergmant, Å
本研究的目的是评估海产品摄入量较高的人群中多溴二苯醚(PBDEs)和多氯联苯(PCbs)及其代谢物多氯联苯(OH-PCb)的血液浓度。从1994-1995年法罗群岛的孕妇和她们7岁的孩子身上获得样本，以检查母体将化合物转移给孩子、与年龄有关的新陈代谢和时间变化。母亲血清中以2，2‘，4，4’-四溴联苯醚(BDE-47)为主，7年后儿童血清中以2，2‘，4，4’，5，5‘六溴联苯醚(BDE-153)为主。母亲和孩子体内的十溴二苯醚含量分别高达每克脂肪重量3和6纳克。儿童体内的Sigma多氯联苯平均浓度约为其母亲的60%，中位数均在1微克/克脂肪重量以上，且具有相似的多氯联苯同系物模式。母亲及其子女的血清中OH-PCBs浓度分别为1.8-36 ng/g湿重(WW)和0.49-22 ng/g WW，除2，3，3‘，4’，5-五氯-4-联苯(4-OH-CB107)外，所有的OH-PCb同系物在儿童中的浓度都较低。7岁的儿童接触到的多氯联苯水平仅略低于他们母亲的水平，儿童体内4-羟基-CB107浓度的增加可能是由于与年龄有关的多氯联苯代谢的差异。母亲和她们的孩子体内的多溴二苯醚浓度相似。儿童体内的主要持久性有机污染物浓度很可能是由于母亲转移以外的其他环境暴露所致。
The objective of this study was to assess blood concentrations of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs), and their polychlorobiphenylol (OH-PCB) metabolites in humans with a high seafood intake. Samples were obtained from pregnant women in the Faroe Islands in 1994-1995 and from their children at 7 years of age to examine maternal transfer of the compounds to their child, age-dependent metabolism, and temporal changes. Maternal serum was dominated by 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), while 2,2',4,4',5,5'hexabromodiphenyl ether (BDE-153) prevailed in the children's serum seven years later. DecaBDE was present in both mothers and children up to 3 and 6 ng/g lipid weight, respectively. The Sigma PCB concentration in the children averaged about 60% of the concentrations in their mothers, with median levels for both above 1 mu g/g lipid weight and with similar PCB congener patterns. Sigma OH-PCB serum concentrations from the mothers and their children showed ranges of 1.8-36 ng/g wet weight (ww) and 0.49-22 ng/g ww, respectively, with all OH-PCB congener concentrations being lower in the children, except for 2,3,3',4',5-pentachloro-4-biphenylol (4-OH-CB107). Children at 7 years of age are exposed to PCBs at levels only slightly below those of their mothers, and the increased 4-OH-CB107 concentrations in children could be due to age-related differences in PCB metabolism. The PBDE concentrations were similar in both mothers and their children. The main persistent organic pollutant concentrations in the children are most probably due to other environmental exposure than maternal transfer.