Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
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DOI：
10.1161/hh1301.093953
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发表时间：
2001-07-06
影响因子：
20.1
通讯作者：
Dimmeler, S
中科院分区：
文献类型：
--
作者：
Vasa, M;Fichtlscherer, S;Dimmeler, S
最近的研究提供了越来越多的证据表明，出生后新生血管涉及骨髓来源的循环内皮祖细胞（EPCs）。目前对冠心病患者内皮祖细胞的调节作用尚不清楚。因此，我们测定了45例CAD患者和15名健康志愿者的EPCs的数量和功能活性。CAD患者中分离的EPCs和循环中CD 34/激酶插入结构域受体（KDR）阳性前体细胞的数量分别显著减少约40%和48%。为了确定动脉粥样硬化危险因素的影响，使用了危险因素评分，包括年龄、性别、高血压、糖尿病、吸烟、CAD阳性家族史和LDL胆固醇水平。危险因素的数量与EPC水平（R=-0.394，P =0.002）和CD 34-/KDR阳性细胞（R=-0.537，P = 0.001）的降低显著相关。
Recent studies provide increasing evidence that postnatal neovascularization involves bone marrow-derived circulating endothelial progenitor cells (EPCs). The regulation of EPCs in patients with coronary artery disease (CAD) is unclear at present. Therefore, we determined the number and functional activity of EPCs in 45 patients with CAD and 15 healthy volunteers. The numbers of isolated EPCs and circulating CD34/kinase insert domain receptor (KDR)positive precursor cells were significantly reduced in patients with CAD by approximate to 40% and 48%, respectively. To determine the influence of atherosclerotic risk factors, a risk factor score including age, sex, hypertension, diabetes, smoking, positive family history of CAD, and LDL cholesterol levels was used. The number of risk factors was significantly correlated with a reduction of EPC levels (R=-0.394, P=0.002) and CD34-/KDR-positive cells (R=-0.537, P