Three cooperative mechanisms required for recovery after brain damage
Three cooperative mechanisms required for recovery after brain damage
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DOI：
10.1038/s41598-019-50946-y
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发表时间：
2019-11-01
影响因子：
4.6
通讯作者：
de Arcangelis, L.
中科院分区：
文献类型：
--
作者：
Berger, D.;Varriale, E.;de Arcangelis, L.
中风是人类残疾的主要原因之一。实验观察表明，在中风后功能活动的恢复过程中，有几种机制被激活。在这里，我们通过解释三种机制所起的作用来揭示大脑是如何恢复的：可塑性适应，过度兴奋和突触发生。我们考虑神经网络中两种不同的损伤：一种是简单地导致有效系统大小减小的扩散损伤，另一种是强烈改变系统自发活动的局部损伤，即中风。实验观察到的恢复机制分别和以组合的方式实现。有趣的是，每种机制都在有限程度上有助于恢复。只有三者的结合应用才能恢复未受损系统的自发活动。这就解释了为什么大脑会触发独立的机制，而这些机制的合作是系统恢复的基本要素。
Stroke is one of the main causes of human disabilities. Experimental observations indicate that several mechanisms are activated during the recovery of functional activity after a stroke. Here we unveil how the brain recovers by explaining the role played by three mechanisms: Plastic adaptation, hyperexcitability and synaptogenesis. We consider two different damages in a neural network: A diffuse damage that simply causes the reduction of the effective system size and a localized damage, a stroke, that strongly alters the spontaneous activity of the system. Recovery mechanisms observed experimentally are implemented both separately and in a combined way. Interestingly, each mechanism contributes to the recovery to a limited extent. Only the combined application of all three together is able to recover the spontaneous activity of the undamaged system. This explains why the brain triggers independent mechanisms, whose cooperation is the fundamental ingredient for the system's recovery.