Protonated (S)-prolinamide derivatives-water compatible organocatalysts for direct asymmetric aldol reaction
Protonated (S)-prolinamide derivatives-water compatible organocatalysts for direct asymmetric aldol reaction
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DOI：
10.1016/j.tetasy.2008.09.020
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发表时间：
2008-10-06
影响因子：
--
通讯作者：
Mahajan, Dinesh
中科院分区：
文献类型：
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作者：
Chimni, Swapandeep Singh;Singh, Sarbjit;Mahajan, Dinesh
质子化的手性脯氨酰胺衍生物是一种水溶性的高效有机催化剂，可用于直接的不对称羟醛缩合反应。由L-脯氨酸和3-硝基苯胺制备的简单质子化（S）-脯氨酰胺有机催化剂催化未修饰的酮和各种芳香醛的羟醛缩合反应，高产率地产生羟醛缩合产物，对映选择性高达98%，非对映选择性高达>99：1。(C)2008爱思唯尔有限公司版权所有。
Protonated chiral (S)-prolinamide derivatives have been developed as water compatible highly efficient organocatalysts for a direct enantioselective aldol reaction. A simple protonated (S)-prolinamide organocatalyst prepared from L-proline and 3-nitroaniline catalyzes the aldol reaction of unmodified ketones and a variety of aromatic aldehydes yielding aldol product in high yield with enantioselectivities of up to 98% and diastereoselectivity of up to >99:1. (C) 2008 Elsevier Ltd. All rights reserved.