MOTOR OUTPUTS OF GIANT NERVE-FIBER IN DROSOPHILA
MOTOR OUTPUTS OF GIANT NERVE-FIBER IN DROSOPHILA
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DOI：
10.1152/jn.1980.44.2.405
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发表时间：
1980-01-01
影响因子：
2.5
通讯作者：
WYMAN, RJ
中科院分区：
文献类型：
--
作者：
TANOUYE, MA;WYMAN, RJ
在脑内电刺激巨纤维，并从其轴突记录细胞内的动作电位。大纤维的单个尖峰驱动tergotrochanter肌（TTM）和背纵肌（DLM）的短和恒定潜伏期肌肉电位。巨纤维通路对高频刺激的反应非常稳定。通向DLM的通路跟随频率高达100hz的刺激。通向TTM的通路跟随频率高达300赫兹的刺激。运动神经元反应被描述为在巨大的纤维尖峰与TTM和DLM肌肉电位之间发生的事件的时间。大部分时间是由于运动神经元轴突传导和神经肌肉传递。大纤维和运动神经元之间传输的时间相对较少。结果与巨纤维通路神经解剖学比较。巨大的纤维可能通过与TTM运动神经元的单突触连接来驱动TTM。这种巨大的纤维通过King和Wyman的外周突触中间神经元（PSI）来驱动DLM运动神经元。进一步提出：大纤维与TTM运动神经元之间的连接是电传输，大纤维与PSI之间的连接是电传输，PSI与DLM运动神经元之间的连接是化学传输。
The giant fiber of D. melnogaster was stimulated electrically in the brain and action potentials were recorded intracellularly from its axon. A single spike in the giant fiber drives short and constant-latency muscle potentials in the tergotrochanter muscle (TTM) and the dorsal longitudinal muscle (DLM). The giant fiber pathway is extremely stable in response to high-frequency stimuli. The pathway to the DLM follows stimuli at frequencies as high as 100 Hz. the pathway to the TTM follows stimuli at frequencies as high as 300 Hz. Motoneuron responses were described to time the events occurring between the giant fiber spikes and the TTM and DLM muscle potentials. Most of this time is due to motoneuron axon conduction and neuromuscular transmission. Relatively less time is due to transmission between the giant fiber and the motoneurons. Results are compared with giant fiber pathway neuroanatomy. The giant fiber may drive the TTM via a monosynaptic connection to the TTM motoneuron. The giant fiber drives the DLM motoneurons disynaptically via the peripherally synapsing interneuron (PSI) of King and Wyman. It is further suggested that: connections between the giant fiber and the TTM motoneuron transmit electrically, connections between the giant fiber and the PSI transmit electrically and connections between the PSI and the DLM motoneurons transmit chemically.