Decision checkpoints in the thymus.
Decision checkpoints in the thymus.
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胸腺中T细胞的发育涉及多个分化和增殖事件，在此期间造血前体产生响应抗原刺激的T细胞并准备进行效应分化。本文综述了控制胸腺内T细胞前体旅程的信号传导和转录检查点。我们专注于αβ和γδ谱系细胞的分歧和αβ T细胞库的阐述，特别强调指导谱系决定的转录程序的出现。
The development of T cells in the thymus involves multiple differentiation and proliferation events during which hematopoietic precursors give rise to T cells responding to antigen stimulation and ready for effector differentiation. This review addresses signaling and transcriptional checkpoints that control the intrathymic journey of T cell precursors. We focus on the divergence of αβ and γδ lineage cells and the elaboration of the αβ T cell repertoire, with special emphasis on the emergence of transcriptional programs that direct lineage decisions.