Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.
Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.
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DOI：
10.1016/j.cmet.2015.07.005
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发表时间：
2015-08-04
期刊：
影响因子：
29
通讯作者：
Gladyshev VN
中科院分区：
文献类型：
--
作者：
Ma S;Yim SH;Lee SG;Kim EB;Lee SR;Chang KT;Buffenstein R;Lewis KN;Park TJ;Miller RA;Clish CB;Gladyshev VN
哺乳动物的生物多样性是显着的。哺乳动物的体重相差七个数量级，不同物种的寿命相差超过 100 倍。虽然遗传、饮食和药理学干预可用于调节模式生物的这些特征，但尚不清楚它们是如何由自然选择决定的。通过分析代表 10 个分类目的 26 种哺乳动物的脑、心脏、肾和肝组织中的代谢物，我们报告了器官、谱系和物种寿命特征的代谢模式。我们的数据表明不同器官的代谢物差异率不同，并揭示了代表器官特异性功能和谱系特异性生理学的模式。我们确定了与物种寿命相关的代谢物，其中一些以前与寿命控制有关。我们还将结果与五种长寿小鼠模型的代谢变化进行了比较，并观察到了一些类似的模式。总的来说，这项研究描述了哺乳动物代谢组根据寿命、系统发育、器官和谱系特化的调整。
Biological diversity among mammals is remarkable. Mammalian body weights range seven orders of magnitude and lifespans differ more than 100-fold among species. While genetic, dietary, and pharmacological interventions can be used to modulate these traits in model organisms, it is unknown how they are determined by natural selection. By profiling metabolites in brain, heart, kidney, and liver tissues of 26 mammalian species representing ten taxonomical orders, we report metabolite patterns characteristic of organs, lineages, and species longevity. Our data suggest different rates of metabolite divergence across organs and reveal patterns representing organ-specific functions and lineage-specific physiologies. We identified metabolites that correlated with species lifespan, some of which were previously implicated in longevity control. We also compared the results with metabolite changes in five long-lived mouse models and observed some similar patterns. Overall, this study describes adjustments of the mammalian metabolome according to lifespan, phylogeny, and organ and lineage specialization.