Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and positron emission tomography
Evaluation of basis function and linear least squares methods for generating parametric blood flow images using 15O-water and positron emission tomography
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DOI：
10.1007/s11307-005-0007-2
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发表时间：
2005-07-01
影响因子：
3.1
通讯作者：
Lammertsma, AA
中科院分区：
文献类型：
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作者：
Boellaard, R;Knaapen, P;Lammertsma, AA
目的：O-15-水正电子发射断层扫描（PET）研究的参数分析允许以高空间分辨率确定血流量（BF）、灌注组织分数（PTF）和分布容积（V-d）。在本文中的基函数和线性最小二乘方法产生的参数流data.Procedures的性能进行了评估：Monte Carlo模拟使用典型的灌注值为脑，肿瘤，和心脏。使用7项脑和10项心肌O-15-水PET研究进行临床评价。使用基函数（BFM）、线性最小二乘法（ILLS）和广义线性最小二乘法（GLLS）计算BF、PTF或V-d。结果：Monte Carlo模拟和人体研究表明，对于低BF值（< 1 ml min（-1）ml（-1）），BF、PTF和V-d的计算精度优于5%。对于高BF（> 2 ml min（-1）ml（-1）），与（G）LLS相比，使用BFM提供了更准确的V-d。结论：一般而言，BFM提供了BF，PTF和V-d的最准确估计值。
Purpose: Parametric analysis of O-15-water positron emission tomography (PET) studies allows determination of blood flow (BF), perfusable tissue fraction (PTF), and volume of distribution (V-d) with high spatial resolution. In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated.Procedures: Monte Carlo simulations were performed using typical perfusion values for brain, tumor, and heart. Clinical evaluation was performed using seven cerebral and 10 myocardial O-15-water PET studies. Basis function (BFM), linear least squares (ILLS), and generalized linear least squares (GLLS) methods were used to calculate BF, PTF, or V-d.Results: Monte Carlo simulations and human studies showed that, for low BF values (< 1 ml min(-1) ml(-1)), BF, PTF, and V-d were calculated with accuracies better than 5% for all methods tested. For high BF (> 2 ml min(-1) ml(-1)), use of BFM provided more accurate V-d compared with (G)LLS.Conclusions: In general, BFM provided the most accurate estimates of BF, PTF, and V-d.