The Association of Active and Passive Smoking With Peripheral Arterial Disease: Results From NHANES 1999-2004
The Association of Active and Passive Smoking With Peripheral Arterial Disease: Results From NHANES 1999-2004
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DOI：
10.1177/0003319708330526
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发表时间：
2009-06-01
期刊：
影响因子：
2.8
通讯作者：
Agarwal, Shikhar
中科院分区：
文献类型：
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作者：
Agarwal, Shikhar
我们的目标是量化不同形式的烟草使用与外周动脉疾病(PAD)之间的联系，并在美国人口中具有全国代表性的大样本中表征二手烟暴露与PAD之间的联系。我们观察到现在和以前吸烟与PAD之间存在显著的相关性。即使在调整了临床和人口统计学变量后，非香烟形式的烟草与PAD之间的相关性也不显著。二手烟与PAD的相关性不显著。有趣的是，烟草暴露的“阈值现象”被证明是PAD发生的原因。与不存在或风险极低的个体相比，血清Cotinine>；155 ng/ml的个体患PAD的风险显著增加。PAD和二手烟暴露之间缺乏联系，加上上述阈值现象，导致LIS推测在动脉粥样硬化的发病机制方面，体循环和下肢血管之间存在显着差异。
We aim to quantify the association between different forms of tobacco use and peripheral arterial disease (PAD) and to characterize the association between secondhand smoke exposure and PAD in a large nationally representative sample of the US population. We observed significant associations between current and former cigarette smoking and PAD. The association between noncigarette forms of tobacco and PAD was not significant even after adjustment for clinical and demographic variables. Secondhand smoke was not significantly associated with PAD. Interestingly, a "threshold phenomenon" for tobacco exposure was demonstrated for PAD Occurrence. Individuals with serum cotinine >155 ng/mL were at significantly higher risk of having PAD as compared with a nonexistent or a minimal risk below this threshold value. Lack of association between PAD and secondhand smoke exposure in conjunction with the threshold phenomenon described above leads Lis to speculate existence of striking differences between the systemic circulation and lower extremity vasculature in terms of pathogenesis of atherosclerosis.