Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T lymphocytes
Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vγ9/Vδ2 T lymphocytes
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DOI：
10.1086/323600
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发表时间：
2001-10-15
影响因子：
6.4
通讯作者：
Salerno, A
中科院分区：
文献类型：
--
作者：
Dieli, F;Troye-Blomberg, M;Salerno, A
V γ 9/V δ 2 T淋巴细胞对结核分枝杆菌免疫保护的贡献仍然是一个有争议的问题。早先报道V γ 9/V δ 2 T淋巴细胞杀死携带活M.通过颗粒依赖性机制杀死细胞内的杆菌。这项研究发现，V γ 9/V δ 2 T淋巴细胞降低细胞外和细胞内M.结核在V γ 9/V δ 2 T淋巴细胞中检测到的颗粒溶素和穿孔素起主要作用，这表明V γ 9/V δ 2 T淋巴细胞直接有助于保护性宿主应答抗M。肺结核感染。
Contribution of V gamma9/V delta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that V gamma9/V delta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that V gamma9/V delta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in V gamma9/V delta2 T lymphocytes, play a major role, which indicates that V gamma9/V deltaT lymphocytes directly contribute to a protective host response against M. tuberculosis infection.