Functional characterization and spatial clustering of visual cortical neurons in the predatory grasshopper mouse Onychomys arenicola.
Functional characterization and spatial clustering of visual cortical neurons in the predatory grasshopper mouse Onychomys arenicola.
复制标题
捕食性蚱蜢小鼠甲鼠视觉皮层神经元的功能特征和空间聚类。
DOI：
10.1152/jn.00779.2016
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发表时间：
2017
影响因子：
2.5
通讯作者：
Priebe,NicholasJ
中科院分区：
文献类型：
--
作者：
Scholl,Benjamin;Pattadkal,JagrutiJ;Rowe,Ashlee;Priebe,NicholasJ
哺乳动物的新皮层回路在功能上是有组织的，使得单个神经元的选择性系统地在皮层表面上移动，形成连续的地图。感觉空间的地图存在于皮层中，例如视觉系统中的视网膜定位图或听觉系统中的音调定位图，但其他功能反应特性也可以类似地组织。例如，许多食肉动物和灵长类动物在初级视觉皮层（V1）中拥有方向选择性地图，而小鼠，兔子和灰松鼠缺乏方向地图。在这份报告中，我们发现一种具有捕食行为的食肉啮齿动物，蝗虫小鼠（Onychomys arenicola），在V1中缺乏一个典型的方向偏好的柱状组织;然而，50 μm内的相邻神经元表现出相关的调谐偏好。使用双光子显微镜和细胞外电生理学的组合，我们证明了在蚱蜢小鼠的视觉皮层神经元的功能组织在很大程度上是相同的C57/BL 6实验室小鼠。我们还发现相似的刺激方向，方向和空间频率的选择性。我们的研究结果表明，啮齿类动物V1神经元的特性在很大程度上是保守的。新&值得注意的是，食肉动物和灵长类动物在初级视觉皮层（V1）中具有方向选择性地图，而啮齿类动物和兔形目动物缺乏这种组织。我们研究，第一次，V1的野生食肉啮齿动物的捕食行为，蝗虫小鼠（Onychomys arenicola）。我们证明了V1在蚱蜢小鼠的细胞组织在很大程度上是相同的C57/BL 6实验室小鼠，这表明V1神经元特性在啮齿动物物种在很大程度上是保守的。
Mammalian neocortical circuits are functionally organized such that the selectivity of individual neurons systematically shifts across the cortical surface, forming a continuous map. Maps of the sensory space exist in cortex, such as retinotopic maps in the visual system or tonotopic maps in the auditory system, but other functional response properties also may be similarly organized. For example, many carnivores and primates possess a map for orientation selectivity in primary visual cortex (V1), whereas mice, rabbits, and the gray squirrel lack orientation maps. In this report we show that a carnivorous rodent with predatory behaviors, the grasshopper mouse (Onychomys arenicola), lacks a canonical columnar organization of orientation preference in V1; however, neighboring neurons within 50 μm exhibit related tuning preference. Using a combination of two-photon microscopy and extracellular electrophysiology, we demonstrate that the functional organization of visual cortical neurons in the grasshopper mouse is largely the same as in the C57/BL6 laboratory mouse. We also find similarity in the selectivity for stimulus orientation, direction, and spatial frequency. Our results suggest that the properties of V1 neurons across rodent species are largely conserved.NEW & NOTEWORTHYCarnivores and primates possess a map for orientation selectivity in primary visual cortex (V1), whereas rodents and lagomorphs lack this organization. We examine, for the first time, V1 of a wild carnivorous rodent with predatory behaviors, the grasshopper mouse (Onychomys arenicola). We demonstrate the cellular organization of V1 in the grasshopper mouse is largely the same as the C57/BL6 laboratory mouse, suggesting that V1 neuron properties across rodent species are largely conserved.