On correlating otoacoustic emissions with blood glucose levels.
On correlating otoacoustic emissions with blood glucose levels.
复制标题
将耳声发射与血糖水平相关联。
DOI：
10.1109/iembs.2008.4650263
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Konrad-Martin,Dawn
中科院分区：
文献类型：
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作者：
Jacobs,PeterG;Wan,EricA;Konrad-Martin,Dawn
这项研究的长期目标是为糖尿病患者开发一种新的方法，以无痛和无创地监测他们的血糖水平。提出了一种基于耳声发射（OAE）测量和分析的无创血糖监测新方法。耳声发射是耳蜗响应于声刺激而产生的低强度声音。诱发和测量耳声发射是使用一个微小的扬声器和麦克风，适合紧贴在耳道内。OAE反应可以通过对侧（对耳）、同侧（同耳）或两者的竞争性声刺激来部分掩蔽或降低振幅。这种掩蔽效应是由大脑神经传出通路的激活引起的。已知神经效应，包括诱发反应，如听觉脑干反应和轴突传递潜伏期，与葡萄糖相关。这表明掩蔽的OAE可能与葡萄糖相关，因为掩蔽是神经活动的结果，而神经活动受葡萄糖水平的影响。在我们的研究之前，没有研究调查了掩蔽的OAE与血糖的相关性。在本文中，我们提出了我们的初步研究结果，包括实验结果表明，与血糖水平的相关性。
The long term objective of this research is to develop a new means for diabetic patients to painlessly and non-invasively monitor their blood glucose levels. We propose a novel method for noninvasive glucose monitoring based on measurement and analysis of otoacoustic emissions (OAEs). OAEs are low-intensity sounds generated by the cochlea in response to acoustic stimuli. Evoking and measuring OAEs is done using a tiny speaker and microphone that fit snugly inside the ear canal. The OAE response can be partially masked or reduced in amplitude by presenting competing acoustic stimuli contralaterally (opposite ear), ipsilaterally (same ear), or both. This masking effect is caused by activation of neural efferent pathways from the brain. Neural effects, including evoked responses such as auditory brainstem responses and axonal transmission latencies, are known to correlate with glucose. This suggests that masked OAEs may correlate with glucose since masking is a result of neural activity, and neural activity is affected by glucose levels. Prior to our research, no studies have investigated the correlation of masked OAEs with blood glucose. In this paper we present our preliminary findings, including experimental results that suggest a correlation with blood glucose levels.