Ultrasonic speed microscopy for imaging of coronary artery
Ultrasonic speed microscopy for imaging of coronary artery
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DOI：
10.1016/j.ultras.2006.06.050
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发表时间：
2006-12-22
期刊：
影响因子：
4.2
通讯作者：
Yambe, Tomoyuki
中科院分区：
文献类型：
--
作者：
Saijo, Yoshifumi;Hozumi, Naohiro;Yambe, Tomoyuki
我们一直在开发一种用于医学和生物学的扫描声学显微镜(SAM)系统，其特点是定量测量超声速度和软组织的衰减。在本研究中，我们将提出一种新的超声速度显微镜的概念，它可以用单个脉冲波的快速傅立叶变换来测量厚度和超声速度，而不是传统的SAM系统中使用的连续波。冰冻冠状动脉6支，切片厚度约10微米。它们被安装在没有盖片的玻璃幻灯片上。对一帧300X300像素的图像进行扫描，扫描时间为121X300，得到了S的二维声速分布。超声速度：胶原纤维增厚内膜为1720m/S，纤维帽下脂肪沉积为1520m/S，钙化病变为1830m/S。这些基本测量将有助于了解血管内超声(IVUS)图像中的回声。超声速度显微镜冠状动脉成像为IVUS冠状动脉成像研究提供了重要信息。(C)2006爱思唯尔B.V.保留所有权利。
We have been developing a scanning acoustic microscope ( SAM) system for medicine and biology featuring quantitative measurement of ultrasonic speed and attenuation of soft tissues. In the present study, we will propose a new concept ultrasonic speed microscopy that can measure the thickness and ultrasonic speed using fast Fourier transform of a single pulsed wave instead of continuous waves used in conventional SAM systems. Six coronary arteries were frozen and sectioned approximately 10 mu m in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 X 300 pixels was 121 s and two- dimensional distribution of ultrasonic speed was obtained. The ultrasonic speed was 1720 m/ s in the thickened intima with collagen fiber, 1520 m/ s in lipid deposition underlying fibrous cap and 1830 m/ s in calcified lesion in the intima. These basic measurements will help understanding echogenecity in intravascular ultrasound ( IVUS) images. Imaging of coronary artery with the ultrasonic speed microscopy provides important information for study of IVUS coronary imaging. (c) 2006 Elsevier B. V. All rights reserved.