Somatostatin: widespread abnormality in tissues of spontaneously diabetic mice.
Somatostatin: widespread abnormality in tissues of spontaneously diabetic mice.
复制标题
生长抑素：自发性糖尿病小鼠组织中广泛存在的异常。
作者：
Y. Patel;D. Cameron;Y. Stefan;F. Malaisse‐Lagae;L. Orci
C57 BL/6 J obob和C57 BL/Ks dbdb品系的糖尿病小鼠显示胰腺生长抑素浓度的降低，伴随着obob品系中胰岛中含生长抑素的细胞数量的显著减少。胃中的生长抑素浓度也降低，但下丘脑中的生长抑素浓度升高。这些研究结果表明，不同的控制机制生长抑素在下丘脑相比，肠道和胰腺，并排除一个主要的遗传异常的生长抑素细胞的突变体。
Diabetic mice of the C57BL/6J obob and C57BL/Ks dbdb strains show a reduction in pancreatic somatostatin concentration accompanied in the obob strain by a striking decrease in the number of somatostatin-containing cells in the islets. Somatostatin concentration is also decreased in the stomach but increased in the hypothalamus. These findings suggest different control mechanisms for somatostatin in the hypothalamus compared to the gut and pancreas and exclude a primary genetic abnormality of somatostatin cells in the mutants.