INTERACTIONS BETWEEN THE AMYGDALA AND VENTRAL STRIATUM IN STIMULUS REWARD ASSOCIATIONS - STUDIES USING A 2ND-ORDER SCHEDULE OF SEXUAL REINFORCEMENT
INTERACTIONS BETWEEN THE AMYGDALA AND VENTRAL STRIATUM IN STIMULUS REWARD ASSOCIATIONS - STUDIES USING A 2ND-ORDER SCHEDULE OF SEXUAL REINFORCEMENT
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DOI：
10.1016/0306-4522(89)90353-9
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发表时间：
1989-01-01
期刊：
影响因子：
3.3
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
--
作者：
EVERITT, BJ;CADOR, M;ROBBINS, TW
双侧，n -甲基- d-天冬氨酸诱导的雄性大鼠杏仁核复合物基底外侧区域损伤导致视觉条件强化物维持的工具反应显著减少，其中性强化在二级时间表下呈现。杏仁核损伤对雄性的非条件性行为没有影响，即对初级强化物引起的行为没有影响。在侧腹纹状体伏隔核区域输注d -安非他命，导致杏仁核损伤后条件强化物维持的工具行为减少呈剂量依赖性改善。d -安非他明的这种作用主要取决于条件强化物的呈现（一种先前中性的光，通过其与性互动的先前关联而获得强化特性）。结果表明，杏仁核基底外侧区域可能与腹侧纹状体多巴胺依赖过程相互作用，介导条件强化物对工具行为的控制。
Bilateral, N-methyl-D-aspartate-induced lesions of the basolateral region of the amygdaloid complex in male rats resulted in a marked decrease in instrumental responses maintained by a visual conditioned reinforcer in a paradigm in which sexual reinforcement was presented under a second-order schedule. There were no effects of lesions of the amygdala on the unconditioned sexual behavior of the males, i.e. on behaviour elicited by primary reinforcers. Infusion of D-amphetamine bilaterally into the nucleus accumbens region of the ventral striatum resulted in a dose-dependent amelioration of the decrease in instrumental behavior maintained by a conditioned reinforcer which followed lesions of the amygdala. This effect of D-amphetamine critically depended upon the presentation of the conditioned reinforcer (a previously neutral light which had gained reinforcing properties through its prior association with sexual interaction). The results indicate that the basolateral region of the amygdala may interact with dopamine-dependent processes in the ventral striatum in mediating the control by conditioned reinforcers over instrumental behaviour.