Area- and band-specific representations of hand movements by local field potentials in the caudal cingulate motor area and supplementary motor area of monkeys
Area- and band-specific representations of hand movements by local field potentials in the caudal cingulate motor area and supplementary motor area of monkeys
复制标题
猴子尾部扣带回运动区和辅助运动区局部场电位对手部运动的区域和带特异性表征
DOI：
10.1152/jn.00882.2015
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发表时间：
2016
影响因子：
2.5
通讯作者：
Eiji Hoshi
中科院分区：
文献类型：
--
作者：
Osamu Yokoyama;Yoshihisa Nakayama;Eiji Hoshi
尾侧扣带运动区(CMAC)和辅助运动区(SMA)在动作执行中起着重要作用。目前的研究通过研究猴子用左手或右手按下按钮时这些区域的局部场电位(LFP)来研究这些作用背后的神经机制。在手部运动中，CMAC和SMA的高伽马(80-120赫兹)和西塔(3-8赫兹)频段的功率增加，而β(12-30赫兹)频段的功率降低。SMA的高伽马和β活动主要代表对侧手的运动，而小脑皮质的活动优先代表两只手的运动。两个大脑区域的Theta活动最常反映的是任一只手的运动，但对侧手的偏向在SMA比在CMAC更明显。对每个记录地点高伽马和theta带之间的偏侧性表示关系的分析表明，无论手对theta带的偏好如何，SMA中的高伽马带优先代表对侧手的运动，而CMAC中的高伽马带代表任何一只手的运动。这些发现表明，在CMAC和SMA中，同侧和对侧手运动的输入输出关系在功能上是不同的。CMAC可以将表示移动的一般方面的输入信号转换成用任一只手执行移动的命令，而SMA可以将输入信号转换成用对侧手执行移动的命令。
The caudal cingulate motor area (CMAc) and the supplementary motor area (SMA) play important roles in movement execution. The present study examined the neural mechanisms underlying these roles by investigating local field potentials (LFPs) from these areas while monkeys pressed buttons with either their left or right hand. During hand movement, power increases in the high-gamma (80–120 Hz) and theta (3–8 Hz) bands and a power decrease in the beta (12–30 Hz) band were observed in both the CMAc and SMA. High-gamma and beta activity in the SMA predominantly represented contralateral hand movements, whereas activity in the CMAc preferentially represented movement of either hand. Theta activity in both brain regions most frequently reflected movement of either hand, but a contralateral hand bias was more evident in the SMA than in the CMAc. An analysis of the relationships of the laterality representations between the high-gamma and theta bands at each recording site revealed that, irrespective of the hand preference for the theta band, the high-gamma band in the SMA preferentially represented contralateral hand movement, whereas the high-gamma band in the CMAc represented movement of either hand. These findings suggest that the input-output relationships for ipsilateral and contralateral hand movements in the CMAc and SMA differ in terms of their functionality. The CMAc may transform the input signals representing general aspects of movement into commands to perform movements with either hand, whereas the SMA may transform the input signals into commands to perform movement with the contralateral hand.