KIDNEY LESIONS ASSOCIATED WITH MORTALITY IN CHICKENS INOCULATED WITH WATERFOWL INFLUENZA-VIRUSES
KIDNEY LESIONS ASSOCIATED WITH MORTALITY IN CHICKENS INOCULATED WITH WATERFOWL INFLUENZA-VIRUSES
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DOI：
10.2307/1591342
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发表时间：
1990-01-01
期刊：
影响因子：
1.4
通讯作者：
EASTERDAY, BC
中科院分区：
文献类型：
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作者：
SLEMONS, RD;LOCKE, LN;EASTERDAY, BC
从威斯康星州、加州、南达科他州、佛罗里达、得克萨斯州、亚拉巴马和内布拉斯加州的水禽中回收的76种A型流感病毒在鸡中进行了毒力测试。对鸡的挑战是静脉接种第一、第二或第三代蛋病毒。每种病毒株分别在三只或四只鸡中进行测试。76种病毒中有18种在接种后导致一只或多只鸡死亡。所有死鸟的死后病变相似。按频率降序排列，肉眼病变包括：肾脏肿胀，表现为小叶图案加重、心包囊内出现尿酸盐和肝脏表面出现尿酸盐。肾脏中存在的显微镜病变与内脏痛风一致。死亡率与感染性病毒浓度较高的接种有关。这些结果表明，鸭群中流行的甲型流感病毒可能包括对鸡有潜在致病性的毒株。
Seventy-six type A influenza viruses recovered from waterfowl in Wisconsin, California, South Dakota, Florida, Texas, Alabama, and Nebraska were tested for virulence in chickens. The challenge to chickens was intravenous inoculation of first-, second-, or third-egg-passage virus. Each of the virus strains was tested separately in three or four chickens. Eighteen of the 76 viruses caused the death of one or more chickens following inoculation. Postmortem lesions were similar in all dead birds. In decreasing order of frequency, gross lesions included: swollen kidneys evident as accentuated lobular patterns, urates in the pericardial sac, and urates on the surface of the liver. Microscopic lesions present in kidneys were consistent with visceral gout. Mortality was associated with inoculations having higher concentrations of infectious virus. These results indicate that the influenza A viruses circulating in duck populations may include strains potentially pathogenic for chickens.