Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels
Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels
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DOI：
10.1007/s00535-016-1234-9
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发表时间：
2017-02-01
影响因子：
6.3
通讯作者：
Hiasa, Yoichi
中科院分区：
文献类型：
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作者：
Miyake, Teruki;Hirooka, Masashi;Hiasa, Yoichi
背景 目前尚不清楚脂肪肝是否是任何患者发生糖耐量异常的危险因素。本研究的目的是根据基线空腹血糖 (FPG) 水平阐明脂肪肝与空腹血糖受损之间的关系。 方法 这项基于社区的纵向队列研究纳入了 7,905 名成年人（3,863 名男性，4,042 名女性；年龄范围为 18-80 岁），他们在 2003 年至 2013 年间至少进行过两次年度检查。 >= 110 mg/dl、服用抗糖尿病药物和/或乙型肝炎表面抗原或抗丙型肝炎病毒抗体检测呈阳性的人被排除在外，从而使 7,203 名参与者符合纳入条件。所有参与者均根据基线 FPG 水平分为四分位数。观察期间 FPG >= 110 mg/dl 被定义为 IFG 发病。结果 7.7% 的男性和 2.1% 的女性出现 IFG (p < 0.001)。在调整年龄、体重指数、收缩压、三酰甘油、高密度脂蛋白胆固醇、尿酸、肌酐、糖尿病家族史、饮酒和当前吸烟情况后，发现在 FPG 水平最高四分位数的两性中，脂肪肝与 IFG 发病呈正相关[男性：调整后风险比 (aHR) 1.823，95% 置信度 区间 (CI) 1.316-2.534，p < 0.001；女性：aHR 2.016，95 % CI 1.117-3.6，p = 0.02]。结论我们的结果表明，脂肪肝与高 FPG 个体发生 IFG 的风险增加独立相关。
Background It remains unclear whether fatty liver is a risk factor for the onset of abnormal glucose tolerance in any patient. The objective of this study was to clarify the relationship between fatty liver and the onset of impaired fasting glucose according to baseline fasting plasma glucose (FPG) levels.Methods This community-based longitudinal cohort study included 7,905 adults (3,863 men, 4,042 women; age range, 18-80 years) who had at least two annual checkups between 2003 and 2013. Those with FPG levels >= 110 mg/dl, taking anti-diabetic agents, and/or testing positive for hepatitis B surface antigen or anti-hepatitis C virus antibody were excluded, leaving 7,203 participants eligible for inclusion. All participants were divided into quartiles derived from their FPG levels at baseline. FPG >= 110 mg/dl during the observation period was defined as onset of IFG.Results Onset of IFG was found in 7.7 % of men and 2.1 % of women (p < 0.001). After adjusting for age, body mass index, systolic blood pressure, triacylglycerol, highdensity lipoprotein cholesterol, uric acid, creatinine, family history of diabetes, alcohol consumption, and current smoking, a positive association was found between fatty liver and the onset of IFG in both sexes with the highest quartile of FPG levels [men: adjusted hazard ratio (aHR) 1.823, 95 % confidence interval (CI) 1.316-2.534, p < 0.001; women: aHR 2.016, 95 % CI 1.117-3.6, p = 0.02].Conclusions Our results suggest that fatty liver is independently associated with an increased risk of developing IFG in individuals with high FPG.