Increased Epithelial Cadherin Expression among Japanese Intestinal-Type Gastric Cancers Compared with Specimens from American Patients of European Descent
Increased Epithelial Cadherin Expression among Japanese Intestinal-Type Gastric Cancers Compared with Specimens from American Patients of European Descent
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DOI：
10.1177/000313480607200412
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发表时间：
2006-04
期刊：
影响因子：
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通讯作者：
C. Theuer;Rasha A Al-Kuran;Y. Akiyama;M. Okumura;A. Žiogas;P. Carpenter
中科院分区：
文献类型：
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作者：
C. Theuer;Rasha A Al-Kuran;Y. Akiyama;M. Okumura;A. Žiogas;P. Carpenter
远东和西方胃癌的不同模式已经发展到这样的程度，即日本的胃癌在生物学上不如西方的侵袭性。我们研究了石蜡包埋、福尔马林固定的组织块，这些组织块来自日本患者和欧洲血统的美国患者，这些患者因胃癌而接受了胃切除术，但不涉及胃食管交界处。对样本进行分期（T 期）、分级（Lauren 分类），并使用免疫组织化学对生物标志物表达（上皮钙粘蛋白 [E-cadherin]、c-erbB2、Ki67 和 p53）进行定量，而无需了解原产国。 E-钙粘蛋白在日本样本中 49% 的恶性细胞中表达，而美国样本中这一比例为 27% (P = 0.04)。两国弥漫性癌症中 E-cadherin 的表达相似（日本为 34.4，美国为 41.5，P = 0.92）。然而，两国肠癌中 E-钙粘蛋白的表达显着较高：来自日本肠癌或混合癌的细胞 (n = 32) 中有 56.3% 表达 E-钙粘蛋白，而美国样本中这一比例为 22.2% (n = 12；P = 0.008)。 c-erbB2 在来自美国样本的恶性细胞中表达比例较高（30% vs 22%；P = 0.20）。 E-钙粘蛋白表达是一种有利的预后因素，在不累及胃食管交界处的日本肠型胃癌中更为常见。如果远东地区胃癌的生物学特性不如美国，那么治疗可能需要个体化。
The different patterns of gastric cancer in the Far East and West have evolved to the extent that it has been suggested that the disease in Japan is biologically less aggressive than in the West. We studied paraffin-embedded, formalin-fixed tissue blocks from Japanese patients and American patients of European descent who had undergone gastrectomy for gastric cancer not involving the gastroesophageal junction. Specimens were staged (T stage), graded (Lauren classification), and biomarker expression (epithelial cadherin [E-cadherin], c-erbB2, Ki67, and p53) was quantified using immunohistochemistry without knowledge of the country of origin. E-cadherin was expressed in 49 per cent of malignant cells from Japanese specimens compared with 27 per cent of malignant cells from American specimens (P = 0.04). The expression of E-cadherin on diffuse cancers from the two countries was similar (34.4 in Japanese vs 41.5 in American, P = 0.92). E-cadherin expression, however, was significantly higher among intestinal cancers from the two countries: 56.3 per cent of cells from intestinal or mixed cancers from Japan (n = 32) expressed E-cadherin compared with 22.2 per cent of American specimens (n = 12; P = 0.008). c-erbB2 was expressed on a higher proportion of malignant cells from American specimens (30% vs 22%; P = 0.20). E-cadherin expression, a favorable prognostic factor, is more common in Japanese intestinal-type gastric cancer not involving the gastroesophageal junction. If the biology of gastric cancer in the Far East is less aggressive than that in the United States, it is likely that treatments need to be individualized.