Regional Comparisons of Optical Coherence Tomography Angiography Vessel Density in Primary Open-Angle Glaucoma
Regional Comparisons of Optical Coherence Tomography Angiography Vessel Density in Primary Open-Angle Glaucoma
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DOI：
10.1016/j.ajo.2016.08.030
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发表时间：
2016-11-01
影响因子：
4.2
通讯作者：
Webers, Carroll A. B.
中科院分区：
文献类型：
--
作者：
Rao, Harsha L.;Pradhan, Zia S.;Webers, Carroll A. B.
目的：比较光学相干断层扫描血管成像(OCTA)对原发性开角型青光眼(POAG)患者视神经头、视乳头周围和黄斑区血管密度的诊断能力，并评价青光眼严重程度(基于平均偏差MD)、视盘大小和治疗前眼压(TOP)的影响。设计：横断面研究。方法：对53例对照组78眼和39例POAG患者眼进行OCTA检查。分析受试者工作特征(ROC)曲线下面积(AUC)和ONH、乳头周围和黄斑区血管密度在固定特异度下的敏感性。结果：ONH血管密度在0.59(鼻上段)~0.73(盘内平均)之间，乳头状周围密度在0.70~0.89之间(鼻、鼻上、颞下)，黄斑区在0.56~0.64之间。平均乳头周围血管密度的AUC明显好于盘内(P=0.05)和黄斑(P=0.005)的平均密度。MD与各区域血管密度的AUC呈负相关。治疗前TOP(系数：0.09)与治疗前相比有显著差异(P
PURPOSE: To compare the diagnostic abilities of the vessel densities in optic nerve head (ONH), peripapillary, and macular regions measured using optical coherence tomography angiography (OCTA) in eyes with primary open-angle glaucoma (POAG), and to evaluate the effect of glaucoma severity (based on the mean deviation, MD), optic disc size, and pretreatment intraocular pressure (TOP).DESIGN: Cross-sectional study.METHODS: Seventy-eight eyes of 53 control subjects and 64 eyes of 39 POAG patients underwent OCTA imaging. Area under receiver operating characteristic (ROC) curves (AUC) and sensitivities at fixed specificities of vessel densities in ONH, peripapillary, and macular regions were analyzed. ROC regression was used to evaluate the effect of covariates on the diagnostic abilities.RESULTS: The AUCs of ONH vessel densities ranged between 0.59 (superonasal sector) and 0.73 (average inside disc), peripapillary between 0.70 (nasal, superonasal and temporal) and 0.89 (inferotemporal), and macular between 0.56 (nasal) and 0.64 (temporal). AUC of the average peripapillary vessel density was significantly better than the average inside disc (P=.05) and macular (P=.005) measurement. MD showed a negative association with the AUCs of the vessel densities of all regions. Pretreatment TOP (coefficient: 0.09) showed a significant (P