fMRI Cortical Correlates of Spontaneous Eye Blinks in the Nonhuman Primate
fMRI Cortical Correlates of Spontaneous Eye Blinks in the Nonhuman Primate
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DOI：
10.1093/cercor/bhu038
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发表时间：
2015-09-01
期刊：
影响因子：
3.7
通讯作者：
Ben Hamed, Suliann
中科院分区：
文献类型：
--
作者：
Guipponi, Olivier;Odouard, Soline;Ben Hamed, Suliann
眨眼被定义为眼睑的快速闭合和打开。眨眼的三种类型被定义为：自发的，反射性的和自愿的。在这里，我们专注于自发性眨眼的皮质相关性，使用功能性磁共振成像（fMRI）在非人类灵长类动物。我们的观察揭示了一个整体的皮层区域处理躯体感觉，本体感受，周边视觉，并可能伤害性眨眼的后果。这些观察结果表明，自发眨眼对大脑视觉皮层以外的影响，可能会污染功能磁共振成像协议，在参与者中产生异质眨眼行为。当这些方案由于苛刻的固定要求而引起（常见的）眼睛疲劳和角膜干燥时，情况尤其如此，如此处的情况。重要的是，在前额叶和顶叶眨眼运动指令区，也没有在前额叶，顶叶和内侧颞叶眨眼抑制区观察到眨眼相关激活。这表明这些区域中不存在激活不是数据中不存在闪烁污染的特征。虽然这些观察增加了我们对自发眨眼的神经基础的理解，但它们也强烈呼吁新的标准来确定fMRI记录是否受到异质眨眼行为的污染。
Eyeblinks are defined as a rapid closing and opening of the eyelid. Three types of blinks are defined: spontaneous, reflexive, and voluntary. Here, we focus on the cortical correlates of spontaneous blinks, using functional magnetic resonance imaging (fMRI) in the nonhuman primate. Our observations reveal an ensemble of cortical regions processing the somatosensory, proprioceptive, peripheral visual, and possibly nociceptive consequences of blinks. These observations indicate that spontaneous blinks have consequences on the brain beyond the visual cortex, possibly contaminating fMRI protocols that generate in the participants heterogeneous blink behaviors. This is especially the case when these protocols induce (nonunusual) eye fatigue and corneal dryness due to demanding fixation requirements, as is the case here. Importantly, no blink related activations were observed in the prefrontal and parietal blinks motor command areas nor in the prefrontal, parietal, and medial temporal blink suppression areas. This indicates that the absence of activation in these areas is not a signature of the absence of blink contamination in the data. While these observations increase our understanding of the neural bases of spontaneous blinks, they also strongly call for new criteria to identify whether fMRI recordings are contaminated by a heterogeneous blink behavior or not.