A neurexin-related protein, BAM-2, terminates axonal branches in C-elegans
A neurexin-related protein, BAM-2, terminates axonal branches in C-elegans
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DOI：
10.1126/science.1089163
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发表时间：
2003-10-10
期刊：
影响因子：
56.9
通讯作者：
Tessier-Lavigne, M
中科院分区：
文献类型：
--
作者：
Colavita, A;Tessier-Lavigne, M
Neuronal axons connect to multiple target cells through the formation of collateral branches, but the mechanisms that regulate this process are largely unknown. We show that BAM-2, a neurexin-related transmembrane protein, is required for development of VC motoneuron branches in the worm Caenorhabditis elegans. Expression analysis and ectopic expression experiments suggest that BAM-2 functions as a branch termination cue and reveal a mechanism for selective control of branches that sprout off a primary axon.
