LEAD-INDUCED HYPERTENSION - POSSIBLE ROLE OF ENDOTHELIAL FACTORS
LEAD-INDUCED HYPERTENSION - POSSIBLE ROLE OF ENDOTHELIAL FACTORS
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DOI：
10.1093/ajh/6.9.723
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发表时间：
1993-09-01
影响因子：
3.2
通讯作者：
PURDY, RE
中科院分区：
文献类型：
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作者：
KHALILMANESH, F;GONICK, HC;PURDY, RE
本研究的结果证实，低铅（0.01%）而非高铅（0.5%）给药可导致治疗长达12个月的大鼠血压升高。这种影响似乎与低铅处理动物中内皮来源的血管收缩剂和血管舒张剂化合物的不平衡有关，而在高铅处理动物中则没有。低铅处理大鼠血浆内皮素1和3 （ET-1和ET-3）测定显示，ET-3浓度在3个月（实验组，92.1 +/- 9.7 v对照，46.7 +/- 12.0 pmol/mL, P < 0.001）和12个月（实验组，105.0 +/- 9.3 v对照，94.1 +/- 5.0 pmol/mL, P < 0.001）后均显著升高
The results of this study confirm that low lead (0.01%) but not high lead (0.5%) administration results in increased blood pressure in rats treated for up to 12 months. This effect appeared to be related to an imbalance of endothelially-derived vasoconstrictor and vasodilator compounds in low lead-treated animals but not in high lead-treated animals. In low lead-treated rats, measurement of plasma endothelins 1 and 3 (ET-1 and ET-3) revealed that ET-3 concentration increased significantly after both 3 months (Experimental, 92.1 +/- 9.7 v Control, 46.7 +/- 12.0 pmol/mL; P < .001) and 12 months (Experimental, 105.0 +/- 9.3 v Control, 94.1 +/- 5.0 pmol/mL; P